氧化三甲胺水平与心房颤动发生风险的meta分析及剂量-反应关系分析

Meta-analysis and dose-response analysis of the relationship between plasma trimethylamine N-oxide level and atrial fibrillation

目的:采用meta分析和剂量-反应关系评价血浆氧化三甲胺水平(TMAO)与心房颤动(AF)发病风险之间的关系。方法:通过计算机搜索中国知网、万方数据库、Pubmed、Embase、Cochrane Library、Web of Science等公开发表的TMAO水平与AF发生的前瞻性队列研究。检索时限从建库至2023年3月,通过纽卡斯尔-渥太华量表(NOS)进行质量评价后提取纳入文献的相关数据,采用Stata 17.0软件进行meta分析及剂量-反应关系分析。结果:共纳入9篇文献,总计531970例研究对象。Meta分析结果显示,TMAO水平与AF发生的风险显著相关(HR=1.42,95%CI 1.12~1.80)。剂量-反应分析显示,血浆TMAO水平与AF发生的风险呈线性剂量-反应关系,血浆TMAO水平每升高1μmol/L,AF发生的风险增加4.06%。结论:血浆TMAO水平与AF发生的风险显著相关。血浆TMAO水平每升高1μmol/L,AF发生的风险增加4.06%。

Objective Meta analysis and a dose-response relationship system were used to assess the relationship between plasma trimethylamine N-oxide(TMAO)level and atrial fibrillation.Methods Databases including CNKI,WanFang Data,PubMed,Embase,Cochrane Library,Web of Science were searched for prospective cohort studies on the relationship between plasma TMAO level and the risk of atrial fibrillation from the establishment of the database to March 2023.The data of the included literatures were extracted,the Newcastle-Ottawa Scale(NOS)was used to evaluate the quality of the included literatures,and Stata 17.0 was used for meta-analysis and dose-response relationship analysis.Results This study included a total of 9 articles with a total of 531970 subjects.The findings of the meta-analysis revealed that the level of TMAO was significantly related to the risk of AF(HR=1.42,95%CI 1.12-1.80).Dose-response analysis showed that there was a linear dose-response relationship between plasma TMAO level and the risk of AF.The risk of AF increased by 4.06%for every 1μmol/L increase in plasma TMAO level.Conclusion There was a significant correlation between plasma TMAO level and the risk of AF.The risk of AF increased by 4.06%for every 1μmol/L increase in plasma TMAO level.