成年人群乳制品摄入与抑郁症状的关联性研究

ASSOCIATION BETWEEN DAIRY CONSUMPTION AND DEPRESSIVE SYMPTOMS IN ANADULT POPULATION

目的通过队列研究设计,探讨成年人群中乳制品摄入与抑郁症状发生之间的关系。方法研究数据来自“天津慢性低度系统性炎症与健康队列研究”,最终纳入研究对象7730名。通过经信效度验证的食物频率问卷(food frequency questionnaire,FFQ)获得乳制品摄入情况;自评抑郁量表(the Zung Self-Rating Depression Scale,SDS)评估抑郁症状;以健康问卷采集研究对象社会人口学特征、生活方式、个人健康基本状况等信息;通过健康体检采集体格检查、实验室检查指标等信息。采用多因素Cox比例风险模型评估不同类型乳制品摄入与抑郁症状发生之间的关联。结果共7730人纳入本研究,男性4450人,女性3280人,中位数随访时间为2年,其中1098人发生抑郁症状,发病密度为73.3/1000人年。调整混杂因素后,与几乎不摄入乳制品(Zero-consumers组)相比,男性人群中总乳制品摄入量tertile1、2、3组HR值(95%CI)分别为0.93(0.73,1.20)、1.04(0.82,1.33)和1.01(0.80,1.29)(趋势性P=0.62),女性人群中为0.79(0.57,1.10)、0.86(0.61,1.19)和0.70(0.50,1.00)(趋势性P=0.08),男性人群中牛奶摄入量HR值(95%CI)分别为0.89(0.71,1.12)、0.90(0.72,1.13)、1.04(0.84,1.30)(趋势性P=0.73),女性人群为0.80(0.62,1.04)、0.72(0.56,0.93)和0.69(0.53,0.89)(趋势性P<0.001);男性人群中酸奶摄入量HR值(95%CI)分别为0.97(0.78,1.21)、0.94(0.75,1.17)、1.00(0.80,1.24)(趋势性P=0.88),女性人群为1.04(0.79,1.36)、0.84(0.62,1.13)、0.93(0.71,1.23)(趋势性P=0.33)。结论研究结果提示,在女性人群中牛奶的摄入量与抑郁症状发生风险呈负相关。

Objective To explore the association between dairy consumption and depressive symptoms in Chinese adults.Methods The data were from the"Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study",which included 7,730 subjects.Dairy intake was assessed using a validated food frequency questionnaire and depressive symptoms were assessed by the Zung Self-Rating Depression Scale.Social demographic characteristics,lifestyle,basic health status and other information were collected by health questionnaire.Information on physical examination and laboratory tests were collected through medical examination.Multivariate Cox proportional hazards model was used to evaluate the association between different types of dairy intake and depressive symptoms.Results A total of 7730 adults were included in this study,including 4450 males and 3280 females.The median follow-up time was 2 years,and 1098 subjects developed depressive symptoms,with an incidence density of 73.3/1000 person-years.After adjusting for confounders,compared to the control group,which consumed almost no dairy,the HR values(95%C)of tertilel,2 and 3 in total dairy intake in males were 0.93(0.73,1.20),1.04(0.82,1.33)and 1.01(0.80,1.29),respectively(trend P=0.62)and in females were 0.79(0.57,1.10),0.86(0.61,1.19)and 0.70(0.50,1.00),respectively(trend P=0.08).The HR values(95%C)of milk intake in males were 0.89(0.71,1.12),0.90(0.72,1.13)and 1.04(0.84,1.30),respectively(trend P=0.73)and in females were 0.80(0.62,1.04),0.72(0.56,0.93)and 0.69(0.53,0.89),respectively(trend P<0.001).The HR values(95%CI)of yogurt intake in males were 0.97(0.78,1.21),0.94(0.75,1.17),1.00(0.80,1.24),respectively(trend P=0.88)and in females were 1.04(0.79,1.36),0.84(0.62,1.13),0.93(0.71,1.23)(trend P=0.33).Conclusion The results suggest that milk intake is negatively correlated with the risk of depressive symptoms in women.