基于脑-肠-微生物轴的肠易激综合征机制与治疗研究进展

Progress in the pathogenesis and treatment of irritable bowel syndrome based on the brain-gut-microbiota axis

肠易激综合征(irritable bowel syndrome,IBS)是常见的功能性肠病之一,目前尚缺乏可用器质性疾病解释的临床特征,最新研究将其机制描述为脑-肠-微生物轴紊乱,强调了肠道微生物群在调节脑肠互动中的中介作用,而中医药对于脑肠稳态调节有着悠久广泛的治疗经验并取得了良好疗效,但两者关联性缺乏论述。因此,本文以脑肠轴为切入点,以肠道微生物作为介质,基于脑肠轴-中医药的良性互动,结合我们相关工作,综述了目前与脑-肠-微生物轴相关的IBS的中西医研究,为同行提供参考。

Irritable bowel syndrome(IBS)is one of the common functional bowel diseases,which lacks clinical features that can be explained by organic diseases.Recent studies describe the pathogenesis of IBS as the disturbance of the brain-gut-microbiota axis,emphasizing the mediating role of gut microbiota in regulating brain-gut interactions.Traditional Chinese medicine(TCM)has been applied to the regulation of brain-gut homeostasis for a long time and demonstrated good efficacy.However,the correlation between TCM and brain-gut homeostasis remains to be studied.We reviewed the TCM and western medicine studies of IBS involving brain-gut-microbiota axis based on the interaction between brain-gut axis and TCM and our previous work,aiming to provide a reference for researchers in this field.