细胞间通信预测方法研究进展

Progress in Study on Intercellular Communication Prediction Methods

基于配体-受体(L-R)互作的细胞间通信是细胞相互协同完成复杂生命活动的重要方式。随着单细胞测序技术的快速发展,在单细胞水平上系统地解析细胞间通信网络及功能迅速成为细胞生物学研究的热点。生物信息学家已开发了大量细胞间信号通信预测的方法及平台,为细胞间信号通信研究提供了重要技术支撑。该文简要阐述了细胞间通信的基本生物学过程;并系统比较了目前较具代表性的细胞间通信预测相关数据库、算法以及评测分析研究;最后系统总结了细胞间通信预测方法的发展趋势,并展望了其未来的研究方向。

Ligand-Receptor(L-R)interactions that mediate cell communication are essential for both physiological and pathological signaling.With the rapid development of single-cell sequencing technologies,decoding the intercellular communication network and biological function has become a focus of research.To date,many intercellular communication prediction methods and databases have been developed and provided key technical supports for researches on cell-cell communication.This study first explains the basic biological process of intercellular communication,then systematically compares representative databases,algorithms,and benchmark studies for predicting intercellular communication.Finally,this study outlines future challenges and outstanding questions in the field.