海南省成年居民高尿酸血症流行病学调查

Epidemiological study of hyperuricemia in adults in Hainan

目的了解海南省成年人高尿酸血症(HUA)患病现状并探索其影响因素。方法本研究采用多阶段整群随机抽样的方法,于2018年10—12月共抽取海南省2个城市和4个县(市)的36个行政村/居委会作为调查点,各调查点根据纳入、排除标准随机均等抽取调查对象,采用问卷调查、身体测量、实验室检测等调查方式,结果采用SPSS 26.0软件进行统计学分析。结果本研究共纳入3604名调查对象,血尿酸水平为(325.19±87.22)μmol/L,男性高于女性(F=897.240,P<0.05),城市居民高于农村(F=24.385,P<0.05)。HUA粗患病率为14.21%,经加权调整后的患病率为15.82%,非条件logistic回归分析结果显示,女性[比值比(OR)=0.135,95%置信区间(CI):0.101~0.181]与HUA风险降低存在关联,≥60岁(OR=1.388,95%CI:1.017~1.895),饮酒频率<3 d/月(OR=1.384,95%CI:1.044~1.834)、1~4 d/周(OR=1.452,95%CI:1.026~2.055)、5~7 d/周(OR=1.726,95%CI:1.278~2.330),超重(OR=1.962,95%CI:1.189~3.238)或肥胖(OR=3.088,95%CI:1.700~5.609)与HUA风险增加存在关联。HUA合并高血糖、血脂紊乱、高血压、超重或肥胖的患者数分别占HUA患者数的63.48%、50.20%、46.09%、43.16%。结论海南省成年人血尿酸水平和HUA患病率均高于全国平均水平,且多数HUA患者合并多种代谢综合征组分。

Objective To understand the prevalence of hyperuricemia in adults in Hainan province and identify its influencing factors.Methods In this study,36 administrative villages/committees in 2 urban areas and 4 rural areas in Hainan were selected for the survey by multi-stage cluster random sampling.Adults in each village or community randomly and equally selected as study subjects according to inclusion and exclusion criteria.The subjects all received questionnaire survey,body measurement and laboratory test.The results were statistically analyzed with software SPSS 26.0.Results A total of 3604 subjects were included in this study,and the average serum uric acid level was(325.19±87.22)μmol/L,the level was higher in men than in women(F=897.240,P<0.05)and in urban residents than in rural residents(F=24.385,P<0.05).The crude prevalence rate of hyperuricemia was 14.21%,and the weighted adjusted prevalence rate was 15.82%.The results of unconditional logistic regression analysis showed that being women[confidence interval(OR)=0.135,95%confidence interval(CI):0.101–0.181]was associated with reduction of hyperuricemia risk,and age≥60 years(OR=1.388,95%CI:1.017–1.895),the frequency of drinking less than 3 d per month(OR=1.384,95%CI:1.044–1.834),1–4 d per week(OR=1.452,95%CI:1.026–2.055),5–7 d per week(OR=1.726,95%CI:1.278–2.330),overweight(OR=1.962,95%CI:1.189–3.238)or obesity(OR=3.088,95%CI:1.700–5.609)were associated with increase of hyperuricemia risk.In addition,the hyperuricemia patients complicated with hyperglycemia,dyslipidemia,hypertension,overweight or obesity accounted for 63.48%,50.20%,46.09%and 43.16%respectively.Conclusion The level of serum uric acid and the prevalence of hyperuricemia in adults in Hainan were higher than the national average,and most hyperuricemia patients were complicated with multiple forms of metabolic syndrome.