口腔黏膜溃疡损害出现短暂自愈的朗格汉斯细胞组织细胞增生症1例

Oral mucosal lesions with transient self-healing of Langerhans cell histiocytosis: a case report

朗格汉斯细胞组织细胞增生症(LCH)是一组原因不明的朗格汉斯细胞组织细胞异常增殖聚集疾病,多发于儿童。LCH分为勒-雪病、汉-许-克病、嗜酸性肉芽肿、先天性自愈性朗格汉斯细胞组织细胞增生症4种临床类型。病损可累及单器官或全身多处器官,临床表现根据累及器官不同而不同,皮肤黏膜可为LCH的首发部位。根据受累器官,LCH有不同的治疗方法,包括手术、放疗、联合化疗等。本文报道1例口腔黏膜溃疡性病损曾经出现短暂自愈的LCH,旨在为罕见病LCH的临床诊疗提供更多参考信息。

Langerhans cell histiocytosis(LCH)is a group of unexplainable abnormal proliferation and aggregation of Langerhans cell.LCH can be classified into four clinical variants:Letterer-Siwe disease,Hand-Schüller-Christian disease,eosinophilic granuloma,and congenital self-healing LCH.LCH is most prevalent in children.Lesions can be localized in a single system or multiple organs,and clinical manifestations vary depending on the affected organs.The skin and mucocutaneous tissues are the starting point of the affected tissue.This study presents a LCH case characterized by transient self-healing.This case can further provide references for the clinical diagnosis and treatment of LCH.