晚期糖基化终末产物形成及抑制机理的研究进展

Research Progress in the Formation and Inhibition Mechanism of Advanced Glycation End Products

晚期糖基化终末产物(advanced glycation end products,AGEs)是由还原糖和蛋白质、脂类或核酸之间通过非酶促反应产生的一系列稳定化合物。研究表明,AGEs在体内过量积累易引发糖尿病、动脉粥样硬化、阿尔茨海默病及心血管疾病等各种慢性病。寻找合适的方法抑制AGEs的形成对保障人体健康具有重要意义,本文主要综述了AGEs的种类、结构、形成过程、致病机理及其体内代谢途径,并重点介绍了AGEs的抑制方式和机理,以期为控制AGEs的形成提供理论依据。

Advanced glycation end products(AGEs)are a series of stable compounds generated by the nonenzymatic reaction of reducing sugars with proteins,lipids or nucleic acids.It has been found that the excessive accumulation of AGEs in the body can easily cause various chronic diseases such as diabetes,atherosclerosis,Alzheimer’s diseases and cardiovascular diseases.Finding methods to suppress the formation of AGEs is of great significance for ensuring human health.This article summarizes the types,structures,formation process,pathogenesis,and in vivo metabolic pathways of AGEs,with a focus on the methods and mechanisms for the inhibition of AGEs.This review will provide a theoretical basis for controlling the formation of AGEs.