海参硫酸多糖与肠道菌群的相互作用及其调节糖脂代谢的研究进展

Research Progress on Interaction between Sulfated Polysaccharides from Sea Cucumber and Gut Microbiota and Its Regulatory Effect on Glycolipid Metabolism

海参作为重要的海洋食品和药物资源,其所含多糖是最重要的功效活性物质之一。硫酸基团在多糖的生物活性中发挥着重要的作用,海参硫酸多糖由于其不同的化学结构而可能特定影响某种肠道微生物的生长及相关代谢物的产生,而这有助于发挥多种健康作用。肠道菌群作为人体的一个复杂生态系统,在营养代谢等生命活动中发挥着不可替代的作用,而海参硫酸多糖可以作为益生元通过调节肠道菌群组成来改善菌群紊乱导致的疾病。本文在介绍海参硫酸多糖结构的基础上,重点阐述了其通过与肠道菌群相互作用影响糖脂代谢的最新相关研究进展。这些研究将有助于更好地理解海参硫酸多糖的健康作用机理,并为其作为功能性食品的应用提供科学依据。

Sea cucumber,an important marine food and medicinal resource,contains polysaccharides,which are one of the most important active substances in it.Sulfate groups play an important role in the biological activity of polysaccharides,and sea cucumber sulfated polysaccharides may specifically affect the growth of certain intestinal microorganisms and the production of related metabolites due to their different chemical structures,which contribute to the variable health promoting effects.As a complex ecosystem of the human body,the intestinalflora plays an irreplaceable role in life activities such as nutritional metabolism.Sea cucumber sulfated polysaccharides can be used as prebiotics to alleviate diseases caused by intestinalflora disorder by regulating its composition.This review article summarizes the structures of sea cucumber sulfated polysaccharides,with a focus on the latest progress in research on their influence on glycolipid metabolism through the gut microbiota.These studies will contribute to a better understanding of the health promoting mechanism of sea cucumber sulfated polysaccharides and provide a scientific basis for their application in functional foods.