基于纤维素-多巴胺羧酸甜菜碱的新型仿生电子皮肤材料研究

Research on novel biomimetic electronic skin materials based oncellulose-dopaminecarboxylic acid betaine

仿生皮肤可模拟人类皮肤,具有感知多种刺激的能力,在医疗监控、人工智能等领域有着广泛的应用。但是传统的电子皮肤材料通常存在机械强度低,黏附性能差,易失水导致柔性丧失等问题,限制了它在电子领域的应用。基于贻贝黏附蛋白,以天然高分子纤维素的衍生物羧甲基纤维素钠为骨架,制备了多巴胺改性的羧甲基纤维素(CMC-DA)的聚合物,并将其引入两性离子材料聚羧基甜菜碱(PCB)水凝胶中。当CMC-DA邻苯二酚基团的取代度为6.8%时,CD-PCB水凝胶具有良好的黏附性能,且可以通过CMC-DA质量分数的不同而调节,同时水凝胶的机械性能均得到较大改善。在此基础上加入天然高分子材料蚕丝蛋白,增强了水凝胶保湿性能。CDP-SILK水凝胶同时具有抑菌性,在金属离子的贯穿网络下,水凝胶获得良好的导电性。总体来说开发了生物相容性良好的两性离子仿生皮肤,该材料具有高保湿性,高粘附性,良好生物形容性以及高导电性,在生物电子应用中显示出良好的柔性可穿戴设备前景。

Bionic skin can simulate human skin with the ability to perceive a variety of stimuli,and has a wide range of applications in medical monitoring,artificial intelligence and other fields.However,traditional electronic skin materials usually have problems such as low mechanical strength,poor adhesion performance,and loss of flexibility due to easy water loss,which limits its application in the field of electronics.In this paper,a polymer of dopamine-modified carboxymethyl cellulose(CMC-DA)was prepared based on mussel adhesin and sodium carboxymethyl cellulose,a derivative of natural polymer cellulose,and introduced into a zwitterionic polycarboxybetaine(PCB)hydrogel.When the substitution degree of CMC-DA catechol group is 6.8%,CD-PCB hydrogel has good adhesion performance,and can be adjusted by different CMC-DA substitution degrees.The mechanical properties of the hydrogel are greatly improved.On this basis,natural polymer material silk protein is added to enhance the moisturizing performance of hydrogel.CDP-SILK hydrogels are also bacteriostatic,and obtain good electrical conductivity under the penetrating network of metal ions.In general,the material has developed a well-biocompatible zwitterionic biomimetic skin,which has high moisturizing,high adhesion,good biodescriptability and high electrical conductivity,showing good prospects for flexible wearable devices in bioelectronic applications.