摘要
目的探索肿瘤患者免疫治疗居家期症状管理的有效方法。方法将132例肿瘤免疫治疗患者随机分为对照组和干预组各66例。对照组给予常规健康教育和护理,干预组在对照组的基础上使用自制自我报告结局手册。干预6个月后,比较两组免疫治疗相关不良反应报告准确率、报告时间、严重程度、症状负担和生存质量。结果对照组与干预组分别有62例、63例完成全程研究。干预组免疫治疗相关不良反应报告准确率显著高于对照组,报告时间显著短于对照组,症状负担轻于对照组,生存质量高于对照组(均P<0.05)。结论自我报告结局手册可帮助患者辨别免疫治疗相关不良反应,提高报告准确性和缩短报告时间,减轻患者的症状负担,提高生活质量。
Objective To explore an effective method for symptom management during home-based immunotherapy for cancer patients.Methods A total of 132 cancer patients undergoing immunotherapy were randomly divided into two groups:the control group(n=66)and the intervention group(n=66).The control group received routine health education and nursing care,while the intervention group additionally used a self-reported outcome manual for reporting immune-related adverse events(irAEs).After a 6-month intervention period,the reporting accuracy,timing of reporting,severity of irAEs,symptom burden,and quality of life were compared between the two groups.Results Among the participants,62 in the control group and 63 in the intervention group completed the entire study.The intervention group showed significantly higher accuracy in reporting irAEs,shorter reporting time,milder symptom burden,and higher quality of life compared with the control group(all P<0.05).Conclusion The use of a self-reported outcome manual can help patients identify irAEs,improve the accuracy and timeliness of reporting,reduce symptom burden,and enhance their overall quality of life.
作者
陈小芳
邾萍
徐仕玲
施如春
谷爱花
张柳柳
Chen Xiaofang;Zhu Ping;Xu Shiling;Shi Ruchun;Gu Aihua;Zhang Liuliu(Department of Oncology,Jiangsu Cancer Hospital,Nanjing 210009,China)
出处
《护理学杂志》
CSCD
北大核心
2023年第18期103-106,111,共5页
Journal of Nursing Science
基金
江苏省卫生健康委科研项目(M2021114)
江苏省肿瘤医院科研项目(ZH202007)。
关键词
肿瘤
免疫治疗
免疫检查点抑制剂
免疫相关性不良反应
自我报告结局手册
患者报告结局
症状负担
生活质量
tumor
immunotherapy
immune checkpoint inhibitors
immune-related adverse events
patient reported outcomes manual
patient reported outcomes
symptom burden
quality of life