局部进展期结肠癌综合治疗现状

Status of comprehensive treatment for locally advanced colon cancer

局部进展期结肠癌包括Ⅲ期和高危Ⅱ期结肠癌(肿瘤浸润深度为T4期),国内外指南均推荐先行手术治疗,术后再行辅助化疗。然而,即使遵循指南进行规范的治疗,也仍然有高达30%的患者出现复发转移。因此,如何改善进展期结肠癌患者的预后一直是临床研究的热点,目前已完成和正在进行的临床试验大多围绕新辅助治疗开展。与直肠癌不同的是,即使在进行了全面的新辅助治疗后,手术在局部进展期结肠癌治疗中的作用仍无可替代。本文就局部进展期结肠癌综合治疗现状作一综述。

Locally advanced colon cancer includes stageⅢand high-risk stageⅡcolon cancer(with tumor invasion depth of T4 stage).Both national and international guidelines recommend surgery as the primary treatment,followed by adjuvant chemothera⁃py.However,even with standardized treatment executed,up to 30%of patients still experience recurrence and metastasis.There⁃fore,strategies to improve the prognosis of patients with advanced colon cancer remains a focal point of research.Most completed and ongoing clinical trials haved focused on neoadjuvant therapy.Unlike rectal cancer,there is not an laternative to sugery when treating locally advanced colon cancer,even after comprehensive neoadjuvant therapy.This article provides a literature review on the current status of comprehensive treatment of locally advanced colon cancer.