医务人员新冠病毒疫苗加强免疫的临床特征及防控管理策略

Analysis of Clinical Characteristics and Prevention and Control Strategies of Booster Immunization with COVID-19 Vaccine in Medical Staff

目的:分析医务人员新冠疫苗第二剂次加强免疫的临床特征。方法:选取2022年12月23日~25日某三级医院行第二剂次加强针接种的医务人员作为调查对象。收集年龄、性别、职业、第二剂次加强针的接种时间、是否感染新冠、相关症状等资料。采用独立样本t检验、Pearson相关性分析完成资料分析。结果:共纳入研究对象227名,平均年龄38.1±11.9岁,女性170例(74.9%),临床科室130例(57.3%)。距离第二剂次加强针接种时间间隔平均21.0±10.1天,最短1天,最长57天。新冠阳性者159例(70.0%);有相关症状者175例(77.1%),其中咳嗽、咽痛、头痛、卡他症状的发生率分别为83.4%、69.1%、60.0%、59.4%。是否感染新冠、是否伴随症状(如咳嗽、咽痛、头痛)的医务人员第二剂次加强针接种时间不同(P<0.05)。结论:尽早规范疫苗接种对预防新冠病毒感染的发生、缓解症状的出现及持续时间均有帮助。未来需进一步提高公众的公共卫生预防认知,高风险人群宜尽早主动免疫,降低被感染风险。

Objective:To analyze the clinical features of secondary booster immunization with the second dose of COVID-19 vaccine in medical staff.Methods:Medical staff who received the second dose of booster injection in a certaintertiary hospital from December 23 to 25,2022 were selected as the investigation subjects.Data such as age,sex,occupation,time of the second booster dose,infection with COVID-19,and related symptoms were collected.Independent sample t test and Pearson correlation analysis were used to complete data analysis.Results:A total of 227 subjects were included in this study.The mean age were 38.1±11.9 years,170(74.9%)women,130 clinical departments(57.3%).The average interval from the second booster dose was 21.0±10.1 days,the shortest was 1 day and the longest was 57 days.There were 159 cases(70.0%)with COVID positive,There were 175 cases(77.1%)with related symptoms,among which the incidence of cough,sore throat,headache and catarrhal symptoms were 83.4%,69.1%,60.0%and 59.4%,respectively.The time of the second dose of booster injection was different among the medical staff who were infected with COVID-19 and had accompanying symptoms(such as cough,sore throat and headache)(P<0.05).Conclusions:Early routine vaccination can help prevent the onset of COVID-19 infection and ease the onset and duration of symptoms.In the future,public awareness of public health prevention should be further improved,and high-risk groups should be actively immunized as soon as possible to reduce the risk of infection.