胃癌患者以慢性贫血为首发表现的高危因素Logistic分析

High risk factors for gastric cancer patients with chronic anemia as first manifestation Logistic analysis

目的:探讨胃癌相关贫血的流行病学特征,为临床诊断和治疗提供参考。方法:回顾性分析2020年6月至2022年6月收治的400例胃癌患者的临床资料,并分析癌症相关贫血的发生情况,观察癌症相关贫血的分布。采用SPSS 23.0统计软件对数据进行分析。其中正态分布的计量资料以(^(-)x±s)表示,采用t检验;计数资料以[例(%)]表示,采用χ^(2)检验。单因素分析癌症相关性贫血的相关因素;多因素采用Logistic回归分析癌症相关性贫血的独立危险因素。P<0.05表示差异有统计学意义。结果:在400例胃癌患者中,248例发生了癌症相关贫血,发生率为62.0%。其中轻度64例,中度128例,重度32例,极重度24例。单因素分析显示,年龄、TNM分期、KPS评分、低蛋白血症和是否接受化疗,差异有统计学意义(P<0.05)。多变量Logistic回归分析显示,年龄>60岁、Ⅲ-Ⅳ期、KPS评分≤60、低蛋白血症和化疗是癌症相关贫血的危险因素。结论:胃癌相关贫血的发病率较高,主要为轻中度,其中年龄>60岁、TNMⅢ-Ⅳ期、KPS评分≤60、低蛋白血症和化疗是癌症相关贫血的危险因素。

Objective To investigate the epidemiological characteristics of gastric carcinoma related anemia and provide reference for clinical diagnosis and treatment.Method Clinical data of 400 patients with gastric cancer admitted from June 2020 to June 2022 were retrospectively analyzed,and the incidence of cancer-related anemia was analyzed.The distribution of cancer-related anemia was observed.SPSS 23.0 statistical software was used to analyze the data.The measurement data of normal distribution are expressed as(^(-)x±s)and t test is adopted.Counting data is expressed as%and tested byχ^(2).Single factor analysis of cancer related anemia related factors;Logistic regression was used in multivariate analysis to analyze the independent risk factors for cancer-related anemia,and P<0.05 indicated statistically significant differences.Result Among 400 patients with gastric cancer,248 developed cancer-related anemia(62.0%).Among them,64 cases were mild,128 were moderate,32 were severe,and 24 were extremely severe.Univariate analysis showed that there were significant differences in age,TNM stage,KPS score,hypoproteinemia and whether to receive chemotherapy(P<0.05).Multivariate logistic regression analysis showed that age>60 years,stageⅢ-Ⅳ,KPS score≤60,hypoproteinemia and chemotherapy were risk factors for cancerrelated anemia.Conclusion The incidence of gastric cancer-related anemia is relatively high,mainly mild to moderate,in which age,TNM stage,KPS score,hypoproteinemia and anti-tumor therapy are risk factors for cancer-related anemia.