摘要
报道了在室温下酯与伯硫醇的硫酯化反应.该方法的优点包括不使用过渡金属、条件温和、官能团耐受性良好、底物范围广泛及对脂肪醇酯和酚酯基团的优异化学选择性.该方法成功地应用于丙磺舒硫酯的合成和顺序键的活化.
The thioesterification of esters with primary aliphatic thiols at room temperature was reported.The advantages of the method include transition-metal-free,mild conditions,good functional group tolerance,broad substrate scope and excellent chemoselectivity with respect to aliphatic alcohol ester and phenolic ester groups.This method was successfully applied to the synthesis of probenecid thioester and sequential bond activation.
作者
石义军
孙馨悦
曹晗
别福升
马杰
刘哲
丛兴顺
Shi Yijun;Sun Xinyue;Cao Han;Bie Fusheng;Ma Jie;Liu Zhe;Cong Xingshun(Engineering and Technology Research Institute of Lunan Coal Chemical Engineering,College of Chemistry,Chemical Engineering and Materials Science,Zaozhuang University,Zaozhuang,Shandong 277160;Xiangyang Public Inspection and Testing Center,Xiangyang,Hubei 441000)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2023年第7期2499-2505,共7页
Chinese Journal of Organic Chemistry
基金
枣庄市科技发展计划(No.2018GH19)
山东省自然科学基金(No.ZR2019QB013)资助项目.
关键词
硫酯化反应
酯
伯硫醇
不使用过渡金属
室温
thioesterification
esters
primary aliphatic thiols
transition-metal-free
room temperature
