摘要
肝细胞癌是全球最常见的恶性肿瘤之一,目前已成为肿瘤相关死亡的第二大病因。随着其发病率和死亡率的逐年攀升,关于其发病机制、进展过程、肿瘤免疫微环境、新药开发等一系列相关研究亟待推进。斑马鱼因其基因组及组织结构与人类高度相似,目前已成为一种不可替代的模拟人类疾病的良好模式生物。利用斑马鱼构建的肝细胞癌模型,包括遗传学模型及异种移植模型,已在揭示肝细胞癌的遗传学病因、疾病的进展过程、肿瘤微环境中免疫细胞的功能以及药物筛选等方面发挥了重要作用。本文系统梳理了斑马鱼肝细胞癌模型的发展历程,比较了不同模型的优缺点,指出了现有模型的不足,并展望了本研究领域未来可能的发展方向。本文综述了近年来利用斑马鱼肝细胞癌模型取得的重要研究进展,从而为肝细胞癌相关研究提供参考。
Hepatocellular carcinoma is one of the most common malignancies and has become the second leading cause of tumor-related death.With its morbidity and mortality increasing annually,studies on its pathogenesis,progression,tumor immune microenvironment,and new drug development need to be advanced.Zebrafish has become an irreplaceable model organism to simulate human diseases because of its high similarity in the genome,tissues,and organs.Zebrafish hepatocellular carcinoma models,including genetic and xenotransplantation models,have played an important role in revealing the genetic etiology of hepatocellular carcinoma,disease progression,functions and interactions of immune cells in the tumor microenvironment,and drug screening.This article systematically reviewed the development history of zebrafish hepatocellular carcinoma models,compared the advantages and disadvantages of various models,highlighted the shortcomings of existing models,and proposed the possible development direction of this research field in the future.This article reviews the important research progress of zebrafish hepatocellular carcinoma models in recent years to provide a reference for hepatocellular carcinoma related research.
作者
屈芷馨
李宪美
张峰华
QU Zhixin;LI Xianmei;ZHANG Fenghua(Key Laboratory of Gastrointestinal Cancer(Fujian Medical University),Ministry of Education,School of Basic Medical Sciences,Fujian Medical University,Fuzhou 350122,China.;Fujian Key Laboratory of Integrative Medicine on Geriatrics,Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2023年第8期1061-1069,共9页
Acta Laboratorium Animalis Scientia Sinica
基金
福建省自然科学基金项目(2023J01541)。
关键词
斑马鱼
肝细胞癌
转基因
异种移植
药物筛选
zebrafish
hepatocellular carcinoma
transgene
xenotransplantation
drug screening Conflicts of Interest:The authors declare no conflict of interest.