鹅膏毒肽中毒动物模型建立的研究进展

Research progress on the establishment of animal models of amanitin poisoning

蘑菇中毒是我国最严重的食品安全问题之一。90%以上蘑菇中毒致人死亡事件是因误食含鹅膏毒肽的蘑菇。目前,关于鹅膏毒肽毒理机制、毒代动力及中毒治疗研究众多,但缺乏不同目的动物模型建立的综述。因此,本文根据实验目的及内容对动物选用、毒药物类型、注射方式及剂量等多方面进行综述,旨在为建立鹅膏毒肽中毒动物模型提供理论依据和参考。

Mushroom poisoning is one of the most serious food safety problems in our country.More than 90%of deaths from mushroom poisoning are due to accidental ingestion of mushrooms containing amanitin.At present,many studies have focused on the toxicological mechanism,toxicokinetics,and treatment of amanitin poisoning,but comprehensive reviews on the establishment of animal models for various purposes are limited.Therefore,in accordance with the purpose and content of the experiment,this article reviews animal selection,types of poison and drugs,and injection method and doses to provide a theoretical basis and reference to establish animal models of amanitin poisoning.