生物制剂在银屑病中的临床应用

Clinical application of biological agents in psoriasis

银屑病是一种慢性复发性炎症性疾病,其中免疫细胞、细胞因子均在其发病中发挥作用。治疗银屑病的传统药物如维A酸、甲氨蝶呤、环孢素等均存在起效慢、疗效有限、不良反应多等局限性。近年来,随着生物制剂的问世及对银屑病发病机制的研究,银屑病的治疗效果和安全性得到了显著提升,其中基于不同靶点的生物制剂的靶向治疗已成为主要的研究热点。本文对银屑病相关生物制剂的作用机制、使用方法、疗效及可能发生的不良反应做一综述。

Psoriasis is a chronic recurrent inflammatory disease,in which immune cells and cytokines play important roles.Traditional drugs for treating psoriasis,such as retinoic acid,methotrexate,and cyclosporine,have limitations such as slow onset,limited efficacy,and numerous adverse reactions.In recent years,with the advent of biological agents,the therapeutic effect and safety of psoriasis have been significantly improved.With the in-depth study of the pathogenesis of psoriasis,targeted therapy based on biological agents with different targets has become a major research hotspot.This article reviews the mechanism of action,methods of use,efficacy,and potential adverse reactions of psoriasis related biologics.