口服与静脉滴注抗生素在经会阴前列腺穿刺活检术中的对比研究

Comparison of oral and intravenous antibiotic therapy in transperineal prostate biopsy

目的:评价在经会阴前列腺穿刺活检术中,口服与静脉滴注抗生素在预防患者感染及其他并发症中的治疗效果。方法:分析2020年1月至2022年11月在北京医院行经会阴前列腺穿刺活检的563例患者的临床资料。依据抗生素给药途径分成口服抗生素组和静脉滴注抗生素组,比较2组患者的肿瘤检出以及包括感染在内的并发症发生情况。结果:2组患者的年龄、前列腺特异性抗原(PSA)、前列腺体积、PSA密度(PSAD)、磁共振PI-RADS评分分布、合并症情况(前列腺增生、尿潴留、糖尿病)差异均无统计学意义(P>0.05)。穿刺术后2组患者的肿瘤检出率、感染发生率、其它非感染并发症发生率以及住院时间差异无统计学意义(P>0.05)。结论:口服抗生素在预防经会阴前列腺穿刺活检术围术期感染发生的临床效果与静脉滴注抗生素等效,值得临床推广应用。

Objective:To evaluate the efficacy of oral and intravenous antibiotics in the prevention of infection and other complications in patients undergoing transperineal prostate biopsy.Methods:A total of 563 patients who underwent transperineal prostate biopsy in Beijing hospital from Jan 2020 to Nov 2022 were analyzed.According to the route of antibiotic administration,the patients were divided into oral antibiotics group and intravenous antibiotics group.Tumor detection rate and incidence of complications including infection were compared between the two groups.Results:There were no significant differences in age,prostate specific antigen(PSA),prostate volume,PSA density(PSAD),PI-RADS score distribution,and incidence of complications(benign prostatic hyperplasia,urinary retention,diabetes)between the two groups(P>0.05).There were no significant differences in tumor detection rate,incidence of infection,incidence of other non-infectious complications and length of hospital stay between the two groups after biopsy(P>0.05).Conclusion:The clinical effect of oral antibiotics in the prevention of perioperative infection in transperineal prostate biopsy is equivalent to that of intravenous antibiotics,which is worthy of clinical application.