摘要
Nonketotic hyperglycemic hemichorea-hemiballismus is a rare syndrome in the clinic,and treatment is often delayed.Hypoglycemic therapy is the most widely used and effective treatment,but some patients experience a slower improvement.Other symptomatic treatment medicines have some degree of side effects.Acupuncture treatment is beneficial for hemichoreahemiballismus.A male patient,aged 59 years,first visited our hospital outpatient department due to motor agitation with involuntary movements of the right limb.He had a history of type 2 diabetes mellitus and poor blood glucose control.His serum glucose was 26.5 mmol/L(normal:4.4-6.1 mmol/L),and magnetic resonance imaging demonstrated an irregular area of high signal intensity in T1-weighted imaging,low signal intensity on T2-weighted imaging,and high signal intensity in the left corpus striatum in T2-FLAIR imaging.Hospitalization was recommended for the patient.After ruling out other possibilities,he was eventually diagnosed with nonketotic hyperglycemic hemichorea-hemiballismus.Intensive glycemic control was immediately started with subcutaneous injection and acupuncture treatment at“governor vessel 13 acupoints”,and the involuntary movements completely disappeared on the ninth day of hospitalization.The pathophysiology of nonketotic hyperglycemic hemichorea-hemiballismus is unclear.Different patient histories lead to different brain tissue conditions,and relapses and uncontrolled blood glucose add difficulties to treatment.According to Traditional Chinese Medicine theory,insufficient kidney essence leads to brain dystrophy and causes the symptoms of hemichorea-hemiballismus.Research evidence has shown that acupuncture at"governor vessel 13 acupoints"has a beneficial treatment effect on nonketotic hyperglycemic hemichorea-hemiballismus.
基金
the China National Natural Science Foundation(82074179):Neuron-astrocyte Interactions Mediated by miRNA in TCC Nuclei Approach to Explore the Mechanism of Acupuncture Intervention in the Central Sensitization of Chronic Migraine
the China Association for Science and Technology Young Talent Lifting Project(2019-2021ZGZJXH-QNRC001)
the Capital Health Development Scientific Research Project Excellent Young Talents(Capital Development 2020-4-2236):Study on the Influence of Acupuncture“Wang's Eight Acupoints”on Pain-related Brain Network of Migraine Without Aura and its Curative Effect Prediction
the Beijing Municipal Education Commission Science and Technology Plan General Project(KM202110025005):Study on Imaging Characteristics and Predictive Imaging Omics of Brain Network Regulation in Patients with Migraine by Acupuncture and Herbal Medicine combined Treatment
the National Key Research and Development Plan(2019YFC1709703):Evidence-based Evaluation and Optimization of“Xuanyang Jieyu Tongluo Zhitong”Acupuncture and Herbal Medicine combined Treatment
the National Administration of Traditional Chinese Medicine:2019 Project of Building Evidence-Practice Capacity for TCM(No.2019XZZXZJ002):Evidence-based Study on Acupuncture Treatment of Dominant Diseases。
