骨肉瘤免疫治疗进展

Research progress of osteosarcoma immunotherapy

骨肉瘤是儿童和年轻人中较常见的原发恶性肿瘤。在过去的30多年中,骨肉瘤患者的治疗进展甚微,尤其是转移性和复发性骨肉瘤。近年来,免疫疗法在各种成人癌症中显示出较好的应用前景,包括非细胞疫苗、DC疫苗、过继细胞疗法、免疫检查点抑制剂和联合疗法等,但其在骨肉瘤中的应用尚未得到开发。因此,本文概述了免疫疗法在骨肉瘤中的应用及其研究进展,旨在为骨肉瘤的免疫治疗提供理论参考。

Osteosarcoma is a common primary malignancy in children and young adults.Over the past 30 years,there has been little progress in treatment of osteosarcoma,especially metastatic and recurrent osteosarcoma.In recent years,immunotherapy has shown promising prospects in various adult cancers,including acellular vaccine,dendritic cells(DC)vaccine,adoptive cell therapy,immune checkpoint inhibitors and combination therapy,but its application in osteosarcoma has not been developed yet.In this paper,the application and research progress of immunotherapy in osteosarcoma are summarized,aiming at providing theoretical reference for immunotherapy of osteosarcoma.