不同种属来源肝素组成与结构分析方法研究进展

Research progress on the composition and structure analysis of heparin from different species

肝素是临床上广泛应用的一种抗凝药物,除抗凝活性外,肝素同时具有抗炎、抗病毒、抗肿瘤、抗疟疾等功能。目前《欧洲药典》、《美国药典》和《中国药典》明确要求肝素及低分子肝素仅限来源自猪肠黏膜,不得混有其他来源肝素。本文简要总结了近年来不同种属来源肝素组成与结构分析方法的研究进展。

Heparin is a widely used clinical anticoagulant.Besides its anticoagulant activity,heparin exhibits many other biological functions,such as anti-inflammation,anti-virus,anti-tumor and anti-malaria.Currently,only porcine intestinal mucosa heparin/LMWH is authorized to be used in EU、USA and China.Heparin from other species is considered as Fake Drug.In this paper,progress on the composition and structure analysis of heparin from different species is briefly summarized.