重度哮喘动物模型构建的研究进展

Advances in establishment of animal models of severe asthma

重度哮喘(severe asthma,SA)患者需要大剂量激素,在联合其他药物治疗才能够维持症状控制,或即使采用上述治疗仍不可控,是目前哮喘研究的难点和热点之一。建立一种稳定可复制、高度模拟SA临床病理特征的实验动物模型,对于深入研究SA的发病机制、药物治疗和预防具有重要意义。本文通过回顾与整理国内外近十年来SA动物模型相关的实验研究,从动物选择、模型制备方法、模型病理表型等方面总结和分析SA动物模型构建的最新进展,为基于动物模型开展的SA基础研究提供参考依据。

Severe asthma,which requires high doses of glucocorticoids in combination with other medications to maintain symptom control or is uncontrollable even with these treatments,is currently a challenge in the clinical management of asthma.The establishment of a stable and reproducible animal model that closely mimics the pathophysiological and clinical characteristics of patients with severe asthma is important for in-depth study of severe asthma pathogenesis,identifying potential therapeutic targets,and developing targeted drugs.This article reviews studies related to the establishment of animal models of severe asthma in the past 10 years and summarizes the recent progress in the establishment and evaluation of animal models of severe asthma from three aspects:selection of the animal,establishment protocols,and model pathological phenotypes.This review summarizes and analyzes the current progress in the establishment of SA animal models,and provides a reference for severe asthma basic research using animal models.