肺动脉高压实验模型的研究进展

Research progress in experimental models of pulmonary arterial hypertension

肺动脉高压是一种慢性进行性疾病,若不及时治疗,最终可导致右心衰竭甚至死亡。为了探讨肺动脉高压的发病机制,寻找有效的治疗方法,必需建立与发病机制相对应的实验模型。本文利用Pubmed、ScienceDirect、Wiley和CNKI检索相关文献,系统地总结了近年来肺动脉高压实验模型的制备方法和研究进展,并对这些实验模型涉及的病理特征进行分类和探讨,以期为肺动脉高压的发病机制研究提供参考。

Pulmonary arterial hypertension is a chronic progressive disease that,if not treated promptly,can ultimately lead to right heart failure and even death.To explore the pathogenesis of pulmonary arterial hypertension and develop more effective treatments,it is necessary to establish an experimental model corresponding to its pathogenesis.In this review,PubMed,ScienceDirect,Wiley,and CNKI were used to search the relevant literature.The establishment method and research progress of experimental models of pulmonary arterial hypertension in recent years were systematically summarized.Moreover,the pathological characteristics involved in these experimental models were classified and discussed to provide a reference to study the pathogenesis of pulmonary arterial hypertension.