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啮齿类动物实验性经前烦躁症模型研究进展

Research progress of experimental premenstrual dysphoria models in rodents
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摘要 经前烦躁症(premenstrual dysphoric disorder,PMDD)是经前期综合征的一种亚型,该病症在育龄女性中具有高患病率,病症包含乳房胀痛、头痛等身体症状以及严重的焦虑、抑郁、易怒等情绪症状。目前PMDD已危及全球女性患者的生命健康,在第五版国际精神障碍诊断与统计手册(the Diagnostic and Statistical Manual of Mental Disorder,Fifth edition ed.DSM-5)中将PMDD判定为抑郁症五种类型之一。目前PMDD的病理机制研究主要集中于激素及受体表达方面,这也是目前动物模型构建的理论基础。而动物模型是联系基础研究与临床研究非常重要的一环,造就能够模拟临床症状的动物模型对于疾病发病机制的探索以及对症药物的研发都至关重要。目前,多种PMDD动物模型虽已被用于实验研究,但仍存在许多局限性,这在一定程度上阻碍了PMDD深层机制的研究。为此本文旨在通过梳理目前已知PMDD的发病机制,探讨现有用于研究的PMDD动物模型,以期为PMDD相关机制研究及药物研发提供参考。 Premenstrual dysphoric disorder(PMDD)is a subtype of premenstrual syndrome with high prevalence in women during their reproductive life.It has physical symptoms such as breast tenderness and headache as well as serious emotional symptoms such as anxiety,depression,and irritability.These symptoms are specific to the menstrual cycle.They appear before menstruation and disappear within a week after its completion.PMDD is a health threat for females.In the Diagnostic and Statistical Manual of Mental Disorder(Fifth edition ed.DSM-5),PMDD is one of the five types of depression.Current studies on the pathological mechanism of PMDD mainly focus on hormone and receptor expression,which is the theoretical basis of animal model establishment.Animal models that recapitulate the clinical symptoms of humans are very important to connect basic research to clinical research,which is also crucial to explore the pathogenesis and develop appropriate drugs.Although many kinds of animal models of PMDD have been used in various studies,many limitations result in a barrier to further investigate PMDD.Therefore,this review collates the pathogenesis research of PMDD and discusses the existing animal models of PMDD to provide a reference for PMDD-related mechanism research and drug development.
作者 许佳玲 刘坤 邢影 胡明会 张浩 李自发 耿希文 魏盛 XU Jialing;LIU Kun;XING Ying;HU Minghui;ZHANG Hao;LI Zifa;GENG Xiwen;WEI Sheng(Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China.;School of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355.;Experimental Center,Shandong University of Traditional Chinese Medicine,Jinan 250355)
出处 《中国比较医学杂志》 CAS 北大核心 2023年第9期90-98,共9页 Chinese Journal of Comparative Medicine
基金 国家自然科学基金面上项目(81974553,82274383) 山东省自然科学基金重大基础研究项目(ZR2020ZD17) 山东中医药大学中医药与脑科学青年科研创新团队(22202101) 泰山学者工程专项(tsqn202211137)。
关键词 经前烦躁症 动物模型 行为学检测 动情周期 激素调控 PMDD animal model behavioral test estrous cycle hormone regulation
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