基于国家专利的中药复方治疗遗精的用药规律研究

Study on the medication rule of Chinese materia medica compound prescription in the treatment of spermatorrhea based on national patent

目的分析国家专利数据库中治疗遗精的中药复方,探究其中用药配伍规律。方法计算机检索中国专利公布公告网中2001年1月至2021年1月发布的治疗遗精的中药复方专利,将数据进行筛选后录入古今医案云平台(V2.3.5),对复方中药物的使用频次、功效、性味归经进行统计分析,并进行关联分析、聚类分析及复杂网络分析。结果共纳入治疗遗精的复方专利170项,涉及441种中药。常用的高频药物前5位分别是枸杞子、熟地黄、菟丝子、山茱萸、当归;复方药物主要以补虚药为主,具有补益肝肾功效的药物使用频次最高;复方中使用频次最高的是温性药物、甘味药物和归肾经的药物;使用频次较高的药对组合有6组;聚类分析得到药物核心组合5组;复杂网络分析得到核心处方1个。结论国家中药复方专利治疗遗精多以补益药为主,适用于治疗肾精不足、阴血不足、劳伤心脾、肾阴亏虚和肾阳亏虚导致的遗精,对临床治疗和新药研发有一定参考意义。

Objective To analyze the Chinese materia medica compound prescription for the treatment of spermatogenesis in the national patent database and explore the rules of drug concerted application.Methods The Chinese materia medica compound prescription patents for the treatment of spermatorrhea from January 2001 to January 2021 were retrieved from the China Patent Announcement Website,and the data were screened and input into the cloud platform of ancient and modern medical records(V2.3.5).The frequency of use,efficacy,nature,flavour,and channel tropism of the drugs in the compound prescription were analyzed statistically,and the correlation analysis,cluster analysis,and complex network analysis were carried out.Results A total of 170 compound prescription patents were included in the treatment of spermatogenesis,involving 441 kinds of Chinese materia medica.The top five commonly used high-frequency drugs were Lycii Fructus,Rehmanniae Radix Praeparata,Cuscutae Semen,Corni Fructus,Angelicae Sinensis Radix.The compound prescription drugs were mainly deficiency tonifying drugs,and the drugs with the function of tonifying liver and kidney had the highest frequency of use.The most frequently used drugs in the compound prescription were warm drugs,sweet drugs,and drugs that belong to kidney channel.There were six groups with higher frequency of use.Five groups of core drug combinations were obtained by cluster analysis.A core prescription was obtained by complex network analysis.Conclusion The national patent of Chinese materia medica compound prescription is mainly used as tonifying drugs in the treatment of spermatorrhea,which is suitable for the treatment of spermatorrhea caused by deficiency of kidney essence,deficiency of yin and blood,overstrain injuring heart and spleen,deficiency of kidney yin and deficiency of kidney yang.It has certain reference significance for clinical treatment and drug discovery.