国家集中带量采购盐酸莫西沙星氯化钠注射液治疗社区获得性肺炎应用效果的真实世界研究

Real-world study on the application effect of national centralized acquisition with quantity of Moxifloxacin Hydrochloride Sodium Chloride Injection in the treatment of community acquired pneumonia

目的比较国家集中带量采购盐酸莫西沙星氯化钠注射液和原研药品治疗社区获得性肺炎(CAP)的效果与安全性。方法回顾性收集河北医科大学第一医院2020年10月至2021年10月收治的CAP患者250例,其中应用国家集中带量采购盐酸莫西沙星氯化钠注射液的患者63例为集采组;应用原研药品的患者187例作为原研组。利用倾向性评分匹配法调整组间差异,比较两组的有效性和安全性。结果匹配后,集采组纳入患者61例,原研组纳入患者111例。两组用药72 h及出院时效果比较,差异均无统计学意义(P>0.05)。出院时,两组体温、C反应蛋白、降钙素原均低于入院时,差异有统计学意义(P<0.05)。出院时,两组体温、C反应蛋白、降钙素原比较,差异均无统计学意义(P>0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论国家集中带量采购盐酸莫西沙星氯化钠注射液与原研药品治疗CAP的效果与安全性相当,临床中可广泛应用。

Objective To compare the efficacy and safety of national centralized acquisition with quantity of Moxifloxacin Hydrochloride Sodium Chloride Injection and innovator drug in the treatment of community acquired pneumonia(CAP).Methods A total of 250 CAP patients admitted to the First Hospital of Hebei Medical University from October 2020 to October 2021 were retrospectively collected.Among them,63 patients who used the national centralized acquisition with quantity of Moxifloxacin Hydrochloride Sodium Chloride Injection were included in the collection group,187 patients who received innovator drug as the innovator drug group.The effectiveness and safety of the two groups were compared after using propensity score matching to adjust the differences between the two groups.Results After matching,61 patients were included in the collection group and 111 patients in the innovator drug group.There was no significant difference in treatment effect between the two groups at 72 h of treatment and discharge(P>0.05).At discharge,the body temperature,C-reactive protein,and procalcitonin in the two groups were lower than those at admission,the differences were statistically significant(P<0.05).There were no significant differences in temperature,C-reactive protein,and procalcitonin between the two groups at discharge(P>0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The efficacy and safety of national centralized acquisition with quantity of Moxifloxacin Hydrochloride Sodium Chloride Injection are comparable to the innovator drug in the treatment of CAP,and can be widely used in clinical practice.