痛泻汤剂治疗脾胃湿热型溃疡性结肠炎的临床效果

Clinical effect of Tongxie Decoction on ulcerative colitis of damp-heat type of spleen and stomach

目的探讨痛泻汤剂治疗脾胃湿热型溃疡性结肠炎的临床效果。方法选取上海中医药大学附属曙光医院2021年6月至2022年8月收治的88例脾胃湿热型溃疡性结肠炎患者,采用随机数字表法将其分为观察组和对照组,各44例。对照组以柳氮磺吡啶片肠溶片治疗,观察组在对照组基础上增加痛泻汤剂治疗。以15天为1个疗程,3个疗程后比较两组临床疗效、中医证候积分、肠黏膜屏障功能、治疗安全性。结果观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组腹泻血便、里急后重、肛门灼热、舌红苔黄积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组二胺氧化酶、内毒素、D-乳酸水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论痛泻汤剂治疗脾胃湿热型溃疡性结肠炎的效果显著,可改善中医证候,提高肠黏膜屏障功能。

Objective To explore the clinical effect of Tongxie Decoction on the treatment of ulcerative colitis of damp-heat type of spleen and stomach.Methods A total of 88 patients with ulcerative colitis of damp-heat type of spleen and stomach admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from June 2021 to August 2022 were selected and they were divided into observation group and control group by random number table method,with 44 cases in each group.The control group was treated with Enteric Coated Sulfamethoxazole Tablets,while the observation group was treated with Tongxie Decoction on the basic of control group.A total of 15 days as a course of treatment,after three courses of treatment,clinical efficacy,the traditional Chinese medicine syndrome scores,intestinal mucosal barrier function,and treatment safety of the two groups were compared.Results The clinical effect of observation group was better than control group,the difference was statistically significant(P<0.05).After treatment,the scores of diarrhea and blood stool,posterior gravity,anal burning,and tongue red and moss yellow in two groups were lower than those before treatment,and the observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the levels of diamine oxidase,endotoxin,and D-lactic acid in two groups were lower than before treatment,and the observation group were lower than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Tongxie Decoction has a significant therapeutic effect on ulcerative colitis of deep-heat type of spleen and stomach,which can improve traditional Chinese medicine syndrome and enhance intestinal mucosal barrier function.