Piezo1在癌症中的作用研究进展

Advances on the Role of Piezo1 in Cancer

Piezo1是机械敏感压电离子通道家族的成员,能够将各种机械刺激转换为电化学信号。在几种恶性肿瘤中Piezo1作为致癌介质起重要作用,它通过多种机制介导多种癌细胞的增殖、迁移和侵袭。多项研究表明,Piezo1的表达与衰老和癌症患者的临床特征有关,使Piezo1有望成为一种新的生物标志物。综述了Piezol的结构、Piezol通道的动力学特性及其在癌症中的作用,以期为Piezo1用于多种癌症的诊断和预后判断以及作为肿瘤生物标志物和治疗靶点提供参考依据。

Piezo1 is a family member of mechanically sensitive piezoelectric ion channels that convert various mechanical stimuli into electrochemical signals.Piezo1 plays an important role in several malignant tumors as a carcinogenic medium,mediating the proliferation,migration and invasion of various cancer cells through various mechanisms.Several studies have linked the expression of Piezo1 to the clinical characteristics of aging and cancer patients,making Piezo1 promising as a new biomarker for the diagnosis and prognosis of several human cancers.This paper summarized the structure of Piezo1,dynamic characteristics of the Piezo1 channel and its function in cancer,which was expected to provide reference for Piezo1 used in diagnosis and prognosis of cancer and tumor biomarker and therapeutic target.