FANCD2的作用机制及其在肿瘤中的研究进展

The function mechanism of FANCD2 and its research progress in tumors

范可尼贫血(FA)是一种常染色体隐性遗传性疾病,也是最常见的遗传性骨髓衰竭综合征,可导致骨髓衰竭、罹患癌症的风险增加以及发育异常。FANCD2是FA基因家族中的一员,已成为FA信号传导的焦点。研究发现,FANCD2在肿瘤的发生发展中发挥重要作用并能够作为铁死亡(ferroptosis)的相关基因参与调节铁死亡。本文对FANCD2的作用机制及其在肿瘤中的研究进展进行综述,以期为疾病的诊断和治疗提供新的方向和思路。

Fanconi anemia(FA)is an autosomal recessive inherited disease and the most common hereditary bone marrow failure syndrome,which can lead to bone marrow failure,increased risk of cancer,and developmental abnormalities.FANCD2 is a member of the FA gene family and has become the focal point of FA signaling.Research has found that FANCD2 plays an important role in the occurrence and development of tumors and can participate in regulating ferroptosis as a related gene.This article reviews the mechanism of action of FANCD2 and its research progress in tumors,in order to provide new directions and ideas for the diagnosis and treatment of diseases.