铁死亡与帕金森病

Ferroptosis and Parkinson′s disease

帕金森病是以黑质区多巴胺能神经元丢失所导致的神经退行性疾病。研究证实,黑质区铁沉积是多巴胺能神经元退行病变的重要因素。铁死亡是2012年首次报道的一种铁依赖性的新型细胞死亡形式,目前在帕金森病中有关铁死亡的研究甚少。本文从铁稳态、铁死亡、脂质过氧化等几个方面介绍了铁死亡形成过程及病理变化,以及铁死亡与帕金森病之间的联系。

Parkinson′s disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra.Research has confirmed that Fe deposition in the substantia nigra is an important factor in the degeneration of dopaminergic neurons.Ferroptosis is a new form of Fe dependent cell death first reported in 2012,and there is currently little research on iron death in Parkinson′s disease.This article introduces the formation process and pathological changes of ferroptosis from several aspects such as iron homeostasis,ferroptosis,and lipid peroxidation,as well as the relationship between ferroptosis and Parkinson′s disease.