卡维地洛治疗冠心病心绞痛的效果观察

Effect Observation of Carvedilol in Treatment of Angina Pectoris of Coronary Heart Disease

目的:探讨卡维地洛治疗冠心病心绞痛的效果。方法:选取2021年1月—2022年1月赤壁市蒲纺医院收治的冠心病心绞痛患者92例作为研究对象,采用随机数字表法分为对照组与观察组,各46例。对照组实施常规治疗,观察组在对照组基础上应用卡维地洛治疗。比较两组治疗效果。结果:治疗3个月后,观察组心绞痛发作频率、心绞痛程度评分均低于对照组,心绞痛持续时间持续时间短于对照组,差异有统计学意义(P<0.001)。治疗3个月后,观察组甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P<0.001)。治疗3个月后,观察组生理功能、精神状态、社会功能、情感活动评分均高于对照组,差异有统计学意义(P<0.001)。治疗3个月后,观察组左心室舒张末期内径、左室收缩末期内径低于对照组,左心室射血分数高于对照组,差异有统计学意义(P<0.001)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.049)。结论:冠心病心绞痛患者在常规治疗基础上应用卡维地洛治疗,可缓解心绞痛症状,改善血脂指标以及心功能指标,提高生活质量,降低不良反应发生率。

Objective:To study the effect of carvedilol in treatment of angina pectoris of coronary heart disease.Methods:A total of 92 patients with angina pectoris of coronary heart disease who received treatment in Chibi City Pufang Hospital from January 2021 to January 2022 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 46 cases in each group.The control group received conventional treatment,and the observation group received carvedilol treatment on the basis of control group.After 3 months of treatment,the therapeutic effect of the two groups was compared.Results:The angina attack frequency and angina severity scores in the observation group were lower than those in the control group,with statistically significant difference(P<0.001).After 3 months of treatment,the levels of triglycerides,total cholesterol and low density lipoprotein cholesterol in the observation group were lower than those in the control group,and the levels of high density lipoprotein cholesterol in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.001).After 3 months of treatment,the physiological function,mental state,social function and emotional activity scores in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.001).After 3 months of treatment,the left ventricular end-diastolic diameter and left ventricular end-systolic diameter in the observation group were lower than those in the control group,and the left ventricular ejection fraction in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.001).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.049).Conclusion:The treatment of carvedilol in patients with angina pectoris of coronary heart disease can relieve angina symptoms,improve blood lipid indexes and cardiac function indexes,improve quality of life,and reduce the incidence of adverse reactions.