B型利钠肽和可溶性生长刺激表达基因2蛋白在心力衰竭诊断中的应用价值分析

Analysis on Application Value of B-Type Natriuretic Peptide and Soluble Suppression of Tumorigenicity-2 in Diagnosis of Heart Failure

目的:探讨B型利钠肽(BNP)和可溶性生长刺激表达基因2蛋白(sST2)在心力衰竭诊断中的应用价值。方法:选取2021年1—5月北京大学第一医院密云医院收治的心力衰竭患者252例作为研究对象,按照纽约心功能分级分为Ⅰ级组(n=114)、Ⅱ级组(n=52)、Ⅲ级组(n=37)、Ⅳ级组(n=49)。比较四组BNP、sST2水平及阳性检出率。结果:四组BNP、sST2水平比较,差异有统计学意义(P<0.001);Ⅱ级组、Ⅲ级组、Ⅳ级组BNP与sST2水平高于Ⅰ级组,Ⅲ级组、Ⅳ级组BNP、sST2水平高于Ⅱ级组,差异有统计学意义(P<0.05)。四组BNP阳性检出率比较,差异有统计学意义(P<0.001);Ⅲ级组、Ⅳ级组BNP阳性检出率高于Ⅰ级组、Ⅱ级组,差异有统计学意义(P<0.05)。四组sST2阳性检出率比较,差异有统计学意义(P<0.001);Ⅲ级组、Ⅳ级sST2阳性检出率高于Ⅰ级组,Ⅳ级组sST2阳性检出率高于Ⅱ级组,差异有统计学意义(P<0.05)。结论:sST2作为心力衰竭诊断标志物,临床应用价值与BNP接近,且抗干扰能力强,对心力衰竭的诊断、监测、预后评估具有独特优势。

Objective:To investigate the application value of B-type natriuretic peptide(BNP)and soluble suppression of tumorigenicity-2(sST2)in the diagnosis of heart failure.Methods:From January 2021 to May 2021,252 patients with heart failure admitted to Peking University First Hospital Miyun Campus were selected as the study subjects.They were divided into gradeⅠgroup(n=114),gradeⅡgroup(n=52),gradeⅢgroup(n=37),and gradeⅣgroup(n=49)according to the New York Heart Association Functional Classification.The levels of BNP and sST2 and the positive detection rate of the four groups were compared.Results:There was a statistically significant difference in the levels of BNP and sST2 among the four groups(P<0.001).The levels of BNP and sST2 in the classⅡgroup,classⅢgroup and classⅣgroup were higher than those in the classⅠgroup,and the levels of BNP and sST2 in the classⅢgroup and classⅣgroup were higher than those in the classⅡgroup,and the difference was statistically significant(P<0.05).There was a statistically significant difference in the positive detection rate of BNP among the four groups(P<0.001).The positive detection rate of BNP in the classⅢgroup and classⅣgroup was higher than that in the classⅠgroup and classⅡgroup,and the difference was statistically significant(P<0.05).There was a statistically significant difference in the positive detection rate of sST2 among the four groups(P<0.001).The positive detection rate of sST2 in the classⅢgroup and classⅣgroup was higher than that in the classⅠgroup,and the positive detection rate of sST2 in the classⅣgroup was higher than that in the classⅡgroup,and the difference was statistically significant(P<0.05).Conclusion:As a diagnostic marker of heart failure,sST2 has a similar clinical application value with BNP and strong antiinterference ability,which has unique advantages in the diagnosis,monitoring and prognosis evaluation of heart failure.