间苯三酚不同给药方案在冻融胚胎移植术患者中的临床应用

Clinical Application of Phloroglucinol in Patients Undergoing Frozen-thawed Embryo Transfer with Different Administration Schemes

目的探讨间苯三酚不同给药方案应用于冻融胚胎移植术中的临床效果。方法选取2020年4月至2022年5月井冈山大学附属医院、瑞州医院及泰和县妇幼保健院的60例行冻融胚胎移植术的患者作为研究对象。依照随机数字表法将患者分为观察组和对照组,各30例。两组均行常规黄体支持,观察组患者持续使用间苯三酚,对照组患者在移植前30~60min肌内注射间苯三酚,比较两组的妊娠结局及其他相关指标。结果检测结果显示:观察组负向波频数低于对照组,差异有统计学意义(P<0.05)。观察组子宫内膜负向蠕动波的消失率、减少率和增加率分别为53.33%、36.67%、10.00%,对照组分别为26.67%、40.00%、33.33%;观察组的消失率高于对照组,增加率低于对照组(P<0.05)。两组转化日子宫螺旋动脉血流比(S/D)、阻力指数(RI)、搏动指数(PI)差异无统计学意义(P>0.05),观察组移植日RI低于对照组,差异有统计学意义(P<0.05)。观察组的临床妊娠率、活产率高于对照组(P<0.05),异位妊娠率、早期流产率和多胎率比较差异无统计学意义(P<0.05)。两组患者治疗过程中均未出现明显的不良反应。结论对冻融胚胎移植术患者持续使用间苯三酚可有效提升临床妊娠率和活产率,同时该药物的安全性相对良好,值得临床借鉴。

Objective To explore the clinical effect of different administration schemes of phloroglucinol in frozen-thawed embryo transfer.Methods From April 2020 to May 2022,60 patients who underwent frozen-thawed embryo transfer in Affiliated Hospital of Jinggangshan University,Ruizhou Hospital and Taihe County Maternal and Child Health Hospital were selected as the research objects.Patients were randomly divided into observation group and control group,30 cases in each group.Both groups received routine luteal support,the observation group continued to use phloroglucinol,the control group received intramuscular injection of phloroglucinol 30~60 min before transplantation.The pregnancy outcome and other related indexes of the two groups were compared.Results The results showed that the frequency of negative waves in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).In the observation group,the disappearance rate,decrease rate and increase rate of negative peristalsis wave in endometrium were 53.33%,36.67%and 10.00%respectively,while in the control group,the corresponding three indexes were 26.67%,40.00%and 33.33%respectively.The disappearance rate of the observation group was higher than that of the control group,and the increase rate was lower than that of the control group,with statistical significance(P<0.05).There was no significant difference in uterine spiral artery blood flow ratio(S/D),resistance index(RI)and pulsatility index(PI)between the two groups on the day of transformation(P>0.05),while the RI of the observation group was lower than that of the control group on the day of transplantation,with statistical significance(P<0.05).The clinical pregnancy rate and live birth rate in the observation group were higher than those in the control group(P<0.05),there was no significant difference in ectopic pregnancy rate,early abortion rate and multiple births rate(P>0.05).There were no obvious adverse reactions in the treatment of the two groups.Conclusion Continuous use of phloroglucinol in patients with frozen-thawed embryo transfer can effectively improve the clinical pregnancy rate and live birth rate,and the safety of this drug is relatively good,which is worthy of clinical reference.