血清免疫球蛋白检验在肝衰竭患者中的应用价值研究

Study on application value of serum immunoglobulin test in patients with liver failure

目的研究血清免疫球蛋白检验在肝衰竭患者中的价值。方法抽取100例肝衰竭患者作为实验组,另选同期100例健康体检者作为对照组。比较实验组入院时与对照组的免疫球蛋白指标[白蛋白(ALB)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)]水平;比较实验组入院时与对照组的临床指标[凝血酶原活动度(PTA)、血清总胆红素(TBIL)]水平;比较实验组发病后不同时间(发病后1~10 d、发病后11~20 d、发病后21~30 d)的免疫球蛋白指标(ALB、IgG、IgA、IgM)水平。结果实验组患者入院时的ALB、IgG、IgA、IgM分别为(37.19±2.53)、(16.14±0.79)、(2.55±0.12)、(2.98±0.09)g/L,均高于对照组的(18.22±6.27)、(10.38±0.62)、(1.51±0.26)、(1.41±0.56)g/L,差异具有统计学意义(P<0.05)。实验组患者入院时的PTA(27.65±2.78)%低于对照组的(64.23±3.11)%,TBIL(399.18±154.21)μmol/L高于对照组的(25.72±5.29)μmol/L,差异具有统计学意义(P<0.05)。实验组发病后不同时间患者的ALB、IgG、IgA、IgM比较,差异具有统计学意义(P<0.05)。结论在分析肝衰竭严重程度方面,血清免疫球蛋白检验效果更佳,能够为疾病诊断、治疗提供有效参考,推广意义显著。

Objective To study the value of serum immunoglobulin test in patients with liver failure.Methods 100 patients with liver failure were selected as the experimental group,and 100 healthy subjects were selected as the control group.Comparison was made on levels of immunoglobulin indexes[albumin(ALB),immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM)]and clinical indicators[prothrombin activity(PTA)and serum total bilirubin(TBIL)]between the experimental group at the time of admission and the control group,as well as the levels of immunoglobulin indexes(ALB,IgG,IgA,IgM)in the experimental group at different times(1-10 d,11-20 d,21-30 d)after the onset of the disease.Results The ALB,IgG,IgA and IgM of the patients in the experimental group at the time of admission were(37.19±2.53),(16.14±0.79),(2.55±0.12)and(2.98±0.09)g/L,which were higher than those of(18.22±6.27),(10.38±0.62),(1.51±0.26)and(1.41±0.56)g/L in the control group,and the differences were statistically significant(P<0.05).PTA of(27.65±2.78)%of patients in the experimental group at the time of admission was lower than that of(64.23±3.11)%in the control group,and TBIL of(399.18±154.21)μmol/L was higher than that of(25.72±5.29)μmol/L in the control group;the differences were statistically significant(P<0.05).The differences in ALB,IgG,IgA and IgM were statistically significant(P<0.05)when comparing patients at different times after the onset of the disease in the experimental group.Conclusion The serum immunoglobulin test is more effective in analyzing the severity of liver failure,which can provide effective reference for the diagnosis and treatment of disease,and contains significant promotion significance.