血塞通联合阿司匹林治疗脑梗死患者的临床疗效研究

Clinical effect of Xuesaitong combined with aspirin on cerebral infarction patients

目的探讨血塞通联合阿司匹林在脑梗死患者治疗中的效果。方法选取86例脑梗死患者为研究对象,采用简单化随机法分为对照组和研究组,每组43例。两组患者入院后均采用常规护理方案进行护理,对照组采用阿司匹林口服治疗,研究组在对照组基础上联用血塞通注射液治疗。比较两组患者治疗前后神经功能、凝血功能、中医证候积分,治疗效果和药物不良反应发生率。结果研究组临床总有效率97.7%明显高于对照组的81.4%,差异有统计学意义(P<0.05)。治疗后,两组患者的美国国立卫生研究院卒中量表(NIHSS)评分均较治疗前降低,且研究组NIHSS评分(5.13±0.67)分低于对照组的(9.57±0.82)分,差异有统计学意义(P<0.05)。治疗后,两组患者中医证候积分均较治疗前降低,且研究组中医证候积分(3.13±0.64)分低于对照组的(6.57±1.02)分,差异有统计学意义(P<0.05)。治疗后,两组患者纤维蛋白原(FIB)低于本组治疗前,活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)均长于本组治疗前,且研究组FIB(3.12±0.23)g/L低于对照组的(4.37±0.31)g/L,APTT(31.06±2.74)s、PT(12.27±1.21)s均长于对照组的(28.67±3.28)、(11.21±2.03)s,差异有统计学意义(P<0.05)。研究组不良反应发生率7.0%(3/43)明显低于对照组的34.9%(15/43),差异具有统计学意义(P<0.05)。结论血塞通联合阿司匹林治疗脑梗死患者临床效果显著,能有效改善患者神经功能、凝血功能和中医证候积分,且安全性良好。

Objective To discuss the effect of Xuesaitong combined with aspirin on cerebral infarction patients.Methods A total of 86 patients with cerebral infarction were randomly divided into control group and study group,with 43 cases in each group.Both groups received routine nursing after admission.The control group was treated with oral aspirin,and the study group was treated with Xuesaitong injection on the basis of the control group.The neurological function,coagulation function and traditional Chinese medicine syndrome score before and after treatment,therapeutic effect,and incidence of adverse drug reactions were compared between the two groups.Results The total clinical effective rate of the study group was 97.7%,which was significantly higher than that of 81.4%of the control group,and the difference was statistically significant(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score in both groups was lower than that before treatment in this group;NIHSS score of(5.13±0.67)points in the study group was lower than that of(9.57±0.82)points in the control group;the differences were statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndrome score in both groups was lower than that before treatment in this group,and the traditional Chinese medicine syndrome score of(3.13±0.64)points in the study group were lower than that of(6.57±1.02)points in the control group.The differences were statistically significant(P<0.05).After treatment,the fibrinogen(FIB)in both groups was lower than that before treatment in this group,and activated partial thromboplastin time(APTT)and thrombin time(PT)were longer than those before treatment in this group;FIB of(3.12±0.23)g/L in the study group was lower than that of(4.37±0.31)g/L in the control group;APTT of(31.06±2.74)s and PT of(12.27±1.21)s in the study group were longer than those of(28.67±3.28)and(11.21±2.03)s in the control group;the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 7.0%(3/43),which was significantly lower than that of 34.9%(15/43)in the control group,and the difference was statistically significant(P<0.05).Conclusion Xuesaitong combined with aspirin in the treatment of cerebral infarction patients has significant clinical effect,which can effectively improve the neurological function,coagulation function and traditional Chinese medicine syndrome score of patients,and has high safety.