干扰素对乙型肝炎病毒相关性HCC患者TACE术后转归的影响分析

Analysis of the effect of interferon on post-TACE regression in patients with hepatitis B virus-associated HCC

目的观察联合使用经导管动脉化疗栓塞(TACE)术和干扰素(IFN)治疗乙型肝炎病毒(HBV)相关性原发性肝癌(HCC)的治疗效果,分析IFN对HBV相关性HCC患者TACE术后转归的影响。方法100例HBV相关性HCC患者,随机分为对照组和观察组,每组50例。对照组给予TACE术治疗,观察组在对照组基础上给予IFN治疗。比较两组患者的近期疗效及细胞免疫指标。结果术后4周,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)及自然杀伤细胞(NK细胞)百分比分别为(65.69±7.03)%、(40.13±8.88)%、(1.50±0.42)、(20.08±4.13)%,均高于对照组的(41.78±12.41)%、(19.59±9.55)%、(0.76±0.45)、(10.80±4.69)%,差异具有统计学意义(P<0.05)。观察组近期总有效率为96.0%,高于对照组的76.0%,差异具有统计学意义(P<0.05)。结论HBV相关性HCC患者TACE术后辅助IFN治疗可以显著提高患者的近期疗效和细胞免疫功能。

Objective To observe the effect of combined transarterial chemoembolization(TACE)and interferon(IFN)in the treatment of hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),and analyze the effect of IFN on post-TACE regression in patients with HBV-associated HCC.Methods A total of 100 patients with HBV-associated HCC were randomly divided into control group and observation group,with 50 cases in each group.The control group was treated with TACE,and the observation group was treated with IFN.The short-term efficacy and cellular immune indexes were compared between the two groups.Results At 4 weeks postoperatively,the percentages of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and percentage of natural killer(NK)cells in the observation group were(65.69±7.03)%,(40.13±8.88)%,(1.50±0.42)and(20.08±4.13)%,which were higher than those of(41.78±12.41)%,(19.59±9.55)%,(0.76±0.45)and(10.80±4.69)%in the control group,and the differences were statistically significant(P<0.05).The short-term total effective rate of the observation group was 96.0%,which was higher than that of 76.0%of the control group,and the difference was statistically significant(P<0.05).Conclusion TACE combined with IFN therapy can significantly improve the short-term efficacy and cellular immune function of HBV-associated HCC patients.