中药复方治疗桥本甲状腺炎研究进展

Research Progress in Treatment of Hashimoto's Thyroiditis with Traditional Chinese Medicine Compound Formula

中药复方治疗桥本甲状腺炎(hashimoto thyroiditis,HT)具有独特优势,主要作用机制为降低甲状腺自身抗体水平、调节Th1/Th2、Treg/Th17及其相关细胞因子平衡、抑制甲状腺细胞凋亡等。目前,针对HT的中医药相关数据挖掘研究已较为全面,可为临床方药选用提供参考,但尚未二次应用于临床,或可进行动物实验及临床观察与现有治疗方案进行疗效对比;缺乏中药复方相关网络药理学研究及实验验证,需进一步挖掘传统中药复方的新适应证;机制研究缺少新的角度,可结合病情分期从中医方-证-机制对应的角度开展研究;现有研究采用的中药复方多为自拟方,有待开展经典方剂的应用研究。此外,采用单纯中医治疗HT、建立一套可推广的诊疗模式、研发有效的中药制剂或可作为今后的研究方向。

Traditional Chinese medicine compound Formula have unique advantages in treatment of Hashimoto's thyroiditis(HT),and the main mechanism is to reduce the level of thyroid autoantibody,regulate Th1/Th2 Treg/Th17 and its related cytokines balance,preventing thyroid cell apoptosis,etc.At present,research on traditional Chinese medicine related data mining for HT has been relatively comprehensive and can provide reference for clinical prescription selection.However,it has not yet been applied in clinical practice,or animal experiments and clinical observations can be conducted to compare the efficacy with existing treatment plans.There is a lack of network pharmacology research and experimental validation related to traditional Chinese medicine prescriptions,further exploration of new indications for traditional Chinese medicine prescriptions is needed.There is also a lack of new perspectives in mechanism research,which can be carried out from the perspective of disease staging or corresponding TCM formulas,syndromes,and mechanisms.The traditional Chinese medicine compound formula used in existing research are mostly self formulated formula,and research on the application of classic formula is needed.In addition,using pure traditional Chinese medicine to treat HT,establishing a applicable diagnosis and treatment model and developing effective traditional Chinese medicine formulations may serve as future research directions.