乌司他丁联合甘草酸二铵治疗急性胰腺炎的效果及对肝功能的影响

Effect of Ulinastatin Combined with Diammonium Glycyrrhizinate in the Treatment of Acute Pancreatitis and Its Influence on Liver Function

目的:研究乌司他丁联合甘草酸二铵治疗急性胰腺炎的效果及对肝功能影响。方法:选取2018年2月—2022年10月泰康同济(武汉)医院接收住院治疗的96例急性胰腺炎患者,按随机数字表法将其分为对照组和观察组,各48例。对照组接受常规基础治疗,同时静脉滴注乌司他丁,在此基础上,观察组给予甘草酸二铵治疗。两组最终观察指标包括治疗总有效率、不良反应发生率及治疗前后的肝功能指标和炎症因子水平。结果:观察组治疗总有效率和治疗后血清及白蛋白(ALB)水平均明显高于对照组(P<0.05);治疗后观察组的血清肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)水平均明显低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:乌司他丁联合甘草酸二铵可明显改善急性胰腺炎病情,抑制炎症反应,促进肝功能恢复,且治疗安全性可靠。

Objective:To study the effect of Ulinastatin combined with Diammonium Glycyrrhizinate in the treatment of acute pancreatitis and its effect on liver function.Method:A total of 96 patients with acute pancreatitis admitted to Taikang Tongji(Wuhan)Hospital from February 2018 to October 2022 were selected.The patients were divided into control group and observation group by random number table method,with 48 patients in each group.The control group received conventional basic therapy along with intravenous infusion of Ulinastatin,based on which the patients in the observation group were given Diammonium Glycyrrhizinate.The final observation indicators of the two groups included the total effective rate of treatment,and the incidence of adverse reactions,the levels of serum inflammatory cytokine and liver function indicators before and after treatment.Result:The total effective rate and serum albumin(ALB)level after treatment in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the serum levels of tumor necrosis factor-α(TNF-α),high-sensitivity C reactive protein(hs-CRP),interleukin-6(IL-6),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Uinastin combined with Diammonium Glycyrrhizinate can significantly improve the condition of acute pancreatitis,inhibit inflammation,promote liver function recovery,and the treatment is safe and reliable.