纤支镜肺泡灌洗术联合常规抗感染治疗对细菌性肺炎患者炎症指标的改善作用

Improvement Effect of Bronchofiberscope Alveolar Lavage Combined with Conventional Antiinfective Therapy on Inflammation in Patients with Bacterial Pneumonia

目的:探讨纤支镜肺泡灌洗术联合抗生素治疗对细菌性肺炎患者炎症指标的影响。方法:将雅安市第二人民医院2021年1—11月收治的80例细菌性肺炎患者用随机数字表法分为对照组和观察组各40例,对照组采用抗生素治疗,观察组在对照组基础上联合纤支镜肺泡灌洗术治疗。连续治疗7 d后,比较两组炎症指标[C反应蛋白(CRP)、血清降钙素原(PCT)、白细胞计数(WBC)、中性粒细胞百分比(NEUT%)及红细胞沉降率(ESR)]变化情况。结果:治疗前观察组血清CRP、PCT、WBC、NEUT%和ESR水平相较于对照组差异均无统计学意义(P>0.05);治疗后两组血清CRP、PCT、WBC和NEUT%水平相较于治疗前均下降(P<0.05),但观察组较对照组下降更明显(P<0.05)。结论:纤支镜肺泡灌洗术联合常规抗感染治疗可有效减轻细菌性肺炎患者的炎症反应。

Objective:To investigate the effect of bronchofiberscope alveolar lavage combined with antibiotic therapy on inflammation in patients with bacterial pneumonia.Method:A total of 80 patients with bacterial pneumonia admitted to the Second People's Hospital of Ya’an from January to November 2021 were randomly divided into control group and observation group,each with 40 cases.The control group was treated with antibiotics,and the observation group were treated with bronchofiberscope alveolar lavage combined with antibiotics.After 7 days of continuously treated,the changes of inflammatory indexes,such as C-reactive protein(CRP),serum procalcitonin(PCT),white blood cell(WBC),neutrophil percentage(NEUT%)and erythrocyte sedimentation rate(ESR)in two groups were compared.Result:There were no significantly different between two groups in the levels of serum CRP,PCT,WBC,NEUT%and ESR before treatment(P>0.05);after treatment,the levels of serum CRP,PCT,WBC and NEUT%in the two groups were decreased compared with those before treatment(P<0.05),but the observation group decreased more significantly than the control group(P<0.05).Conclusion:Bronchofiberscope alveolar lavage combined with conventional anti-infective therapy can effectively reduce the inflammatory response in patients with bacterial pneumonia.