阿立哌唑+氟哌啶醇治疗抽动秽语综合征患儿的药理及对ASO水平的影响

Pharmacology of Aripiprazole Combined with Haloperidol in the Treatment of Tics-coprolalia Syndrome Children and Its Effect on ASO Levels

目的:观察阿立哌唑+氟哌啶醇联合治疗对抽动秽语综合征患儿的效果,探讨药理机制,并观察联合治疗对抗链球菌溶血素O(ASO)水平的影响。方法:选择福建省儿童医院2021年5月—2022年5月收治的122例抽动秽语综合征患儿,随机分为对照组和观察组,各61例,对照组采取氟哌啶醇治疗,观察组在此基础上增加阿立哌唑治疗。随访12周,对比两组临床疗效、神经功能指标、ASO水平和药物不良反应。结果:治疗后观察组运动性抽动、发声性抽动耶鲁综合抽动严重程度量表(YGTSS)评分均低于对照组,差异均有统计学意义(P<0.05);观察组总有效率高于对照组,差异有统计学意义(P<0.05);观察组多巴胺(DA)、5-羟色胺(5-HT)、ASO水平均低于对照组,γ-氨基丁酸(GABA)水平高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率对比差异无统计学意义(P>0.05)。结论:阿立哌唑联合氟哌啶醇可有效改善抽动秽语综合征患儿运动性抽动和发声性抽动症状,降低ASO水平,具有安全性。

Objective:To investigate the effect of Aripiprazole combined with Haloperidol in the treatment of tics-coprolalia syndrome children,explore the pharmacological mechanism and observe the effect of combined treatment on antistreptolysin O(ASO)levels.Method:A total of 122 children with tics-coprolalia syndrome admitted to Fujian Children's Hospital from May 2021 to May 2022 were randomly divided into the control group and the observation group,with 61 cases each group.The control group was treated with Haloperidol,and the observation group was treated with Aripiprazole combined with Haloperidol.After 12 weeks of follow-up,clinical efficacy,neurological function indexes,ASO levels and adverse drug reactions were compared between the two groups.Result:After treatment,the Yale global tic severity scale(YGTSS)scores of motor tic and vocal tic in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05);the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05),the levels of dopamine(DA),5-hydroxytryptamine(5-HT)and ASO in the observation group were lower than those in the control group,the level ofγ-aminobutyric acid(GABA)was higher than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Aripiprazole combined with Haloperidol can effectively improve motor tic and vocal tic symptoms in children with tics-coprolalia syndrome,and reduce the level of ASO,it is safety.