盐酸氨溴索联合阿奇霉素治疗儿童肺炎支原体肺炎的效果评价

Evaluation of the Effect of Ambroxol Hydrochloride Combined with Azithromycin in the Treatment of Mycoplasma Pneumoniae Pneumonia in Children

目的:探究儿童肺炎支原体肺炎应用盐酸氨溴索联合阿奇霉素治疗的临床效果。方法:选取2019年8月—2022年8月新余市中医院儿科收治的120例肺炎支原体肺炎患儿,按照随机数字表法将其平均分为对照组(60例)和观察组(60例),分别实施阿奇霉素治疗和阿奇霉素联合盐酸氨溴索治疗。比较两组肺功能、临床指标恢复用时、炎症反应、临床疗效及不良反应发生率。结果:治疗前,两组肺功能各项指标比较,差异均无统计学意义(P>0.05);治疗后,观察组肺功能指标水平均显著高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组临床指标恢复用时均明显短于对照组(P<0.05)。治疗前,两组炎症因子水平比较,差异均无统计学意义(P>0.05);治疗后,观察组白细胞介素-6(IL-6)、C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)水平均显著低于对照组,差异均有统计学意义(P<0.05)。观察组临床总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:肺炎支原体肺炎患儿应用盐酸氨溴索联合阿奇霉素治疗,能够显著改善患儿肺部功能、缩短临床指标恢复用时、减轻炎症反应。

Objective:To explore the clinical effect of using Ambroxol Hydrochloride combined with Azithromycin in the treatment of mycoplasma pneumoniae pneumonia in children.Method:A total of 120 children with mycoplasma pneumoniae pneumonia treated in the Department of Pediatrics of Xinyu Hospital of Traditional Chinese Medicine from August 2019 to August 2022 were selected.They were equally divided into the control group(60 cases)and the observation group(60 cases)by the random number table method,Azithromycin treatment and Azithromycin combined with Ambroxol Hydrochloride treatment were administered sparately.Lung function,recovery of clinical indicators,inflammatory reaction,clinical efficacy and incidence of adverse effects were compared between the two groups.Result:Before treatment,there were no significant differences in lung function indexes between the two groups(P>0.05);after treatment,the levels of lung function indexes in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Recovery of clinical indicators of children in the observation group were significantly shorter than those in the control group(P<0.05).There were no significant differences in the levels of inflammatory factors between the two groups before treatment(P>0.05);after treatment,the levels of interleukin-6(IL-6),C reactive protein(CRP),and serum amyloid A(SAA)in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The total clinical response rate in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment of Ambroxol Hydrochloride combined with Azithromycin in the treatment of children with mycoplasma pneumoniae pneumonia can significantly improve lung function,recovery of clinical indicators,and reduce inflammatory reactions.