复方太子参颗粒治疗小儿厌食症回顾性研究

Retrospective Study on the Treatment of Anorexia in Children with Compound Taizishen Granules

目的:探讨复方太子参颗粒治疗小儿厌食症的效果。方法:回顾性分析2018年2月—2022年2月厦门市儿童医院收治的310例小儿厌食症患者临床资料。根据治疗方法不同分为观察组(n=160,复方太子参颗粒治疗)和对照组(n=150,葡萄糖酸锌口服液治疗)。比较两组治疗效果,中医症候积分、微量元素(铁、锌)及血清相关因子[瘦身素(Leptin)、神经肽Y(NPY)、饥饿激素(Ghrelin)]。结果:观察组治疗后的总有效率(88.75%)高于对照组(73.33%)(P<0.05)。治疗后,两组食量、口臭、大便性状、腹胀中医症候积分较治疗前均降低,且观察组上述积分[(1.72±0.31)、(1.29±0.21)、(1.45±0.21)、(1.52±0.28)分]均明显低于对照组[(2.41±0.34)、(1.78±0.24)、(1.99±0.42)、(2.01±0.30)分](P<0.05)。治疗后,两组微量元素(铁、锌)较治疗前均升高,且观察组上述微量元素[(15.21±2.94)、(14.21±1.94)μmol/L]均高于对照组[(13.21±2.51)、(11.01±1.67)μmol/L](P<0.05)。治疗后,两组Leptin水平较治疗前均降低,且观察组低于对照组,NPY、Ghrelin水平较治疗前均升高,且观察组上述指标均高于对照组(P<0.05)。两组治疗后均无肝肾功能异常现象,未见显著肠道反应。结论:复方太子参颗粒治疗小儿厌食症效果理想,可有效调节微量元素及血清细胞因子水平,且治疗期间无不良反应,安全性高。

Objective:To explore the effect of Compound Taizishen Granules in the treatment of infantile anorexia.Method:The clinical data of 310 children with anorexia treated in Xiamen Children's Hospital from February 2018 to February 2022 were retrospectively analyzed.According to different treatment methods,they were divided into the observation group(n=160,treated with Compound Taizishen Granules)and the control group(n=150,treated with Zinc Gluconate Oral Solution).The therapeutic effects,the changes of TCM syndrome scores,trace elements(iron,zinc)and serum related factors(leptin,NPY,Ghrelin)of the two groups were compared.Result:The total effective rate of the observation group(88.75%)after treatment was higher than that of the control group(73.33%)(P<0.05).After treatment,the TCM syndrome scores of food intake,bad breath,stool character,abdominal distension in the two groups were lower than those before treatment,and the above scores of the observation group[(1.72±0.31),(1.29±0.21),(1.45±0.21),(1.52±0.28)points]were significantly lower than those in the control group[(2.41±0.34),(1.78±0.24),(1.99±0.42),(2.01±0.30)points](P<0.05).After treatment,both groups of trace elements(iron,zinc)increased compared to before treatment,and those[(15.21±2.94),(14.21±1.94)μmol/L]in the observation group were higher than those[(13.21±2.51),(11.01±1.67)μmol/L]in the control group(P<0.05).After treatment,the leptin levels in both groups were lower than those before treatment,and that in the observation was lower than that in the control group,the levels of NPY and Ghrelin in two groups were higher than those before treatment,the levels of NPY and Ghrelin in the observation group were higher than those in the control group(P<0.05).There was no abnormal liver and kidney function and no significant intestinal reaction in both groups after treatment.Conclusion:Compound Taizishen Granules has an ideal effect in the treatment of infantile anorexia,can effectively regulate the levels of trace elements and serum cytokines,and has no adverse reactions during the treatment period,and it is safety.