益气养阴化湿方联合中医禁食疗法治疗脾虚痰湿型代谢综合征临床研究

Clinical Study on Yiqi Yangyin Huashi Prescription Combined with Fasting Treatment in Chinese Medicine for Metabolic Syndrome of Spleen Deficiency with Phlegm-Damp Type

目的:观察益气养阴化湿方联合中医禁食疗法治疗脾虚痰湿型代谢综合征的临床疗效。方法:选择90例脾虚痰湿型代谢综合征患者,按随机数字表法分为观察组和对照组各45例,对照组接受西医治疗,观察组在对照组基础上接受益气养阴化湿方联合中医禁食疗法治疗。连续治疗12周后,比较2组临床疗效及治疗前后中医证候积分、腰围、体质量指数(BMI)、血压、血糖、血脂和血清炎性因子水平。结果:观察组总有效率91.11%,高于对照组73.33%(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05);治疗后,2组中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组腰围、BMI、收缩压、舒张压比较,差异无统计学意义(P>0.05);治疗后,2组腰围、BMI、收缩压、舒张压均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组腰围、BMI、收缩压、舒张压比较,差异无统计学意义(P>0.05);治疗后,2组腰围、BMI、收缩压、舒张压均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血浆致动脉粥样硬化指数(AIP)水平比较,差异无统计学意义(P>0.05);治疗后,2组FBG、TG、TC、LDL-C、AIP水平均降低(P<0.05),且观察组低于对照组(P<0.05)。2组治疗前后HDL-C水平比较,差异均无统计学意义(P>0.05)。治疗前,2组血清肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平比较,差异无统计学意义(P>0.05);治疗后,2组血清TNF-α、hs-CRP、IL-6水平均降低(P<0.05),且观察组低于对照组(P<0.05)。结论:益气养阴化湿方联合中医禁食疗法治疗脾虚痰湿型代谢综合征效果显著,可有效改善临床症状,纠正代谢紊乱状态,减轻炎症反应。

Objective:To observe the clinical effect of therapy of Yiqi Yangyin Huashi Prescription combined with fasting treatment in Chinese medicine on metabolic syndrome of spleen deficiency with phlegm-damp type.Methods:A total of 90 patients with metabolic syndrome of spleen deficiency with phlegm-damp type were selected and divided into the observation group and the control group according to the random number table method,with 45 cases in each group.The control group was given western medicine for treatment,and the observation group was additionally treated with therapy of Yiqi Yangyin Huashi Prescription combined with fasting treatment in Chinese medicine based on the treatment of the control group.After 12 weeks of treatment,the clinical effects was compared between the two groups.And the traditional Chinese medicine(TCM)syndrome scores,waistline,body mass index(BMI),blood pressure,blood sugar,blood fat and levels of serum inflammatory factors compared were before and after treatment between the two groups.Results:The total effective rate was 91.11%in the observation group,higher than that of 73.33%in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of TCM syndrome scores between the two groups(P>0.05);after treatment,the TCM syndrome scores in the two groups were decreased(P<0.05),and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparisons of waistline,BMI,systolic pressure and diastolic pressure between the two groups(P>0.05);after treatment,the waistline,BMI,systolic pressure and diastolic pressure in the two groups were decreased(P<0.05),and the above four levels in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparisons of levels of fasting blood glucose(FBG),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and plasma atherogenic index(AIP)between the two groups(P>0.05);after treatment,the levels of FBG,TG,TC,LDL-C and AIP in both groups were decreased(P<0.05),and the above five levels in the observation group were lower than those in the control group(P<0.05).Before and after treatment,there was no significant difference being found in the comparison of HDL-C level between the two groups(P>0.05).Before treatment,there was no significant difference being found in the comparisons of levels of serum tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)between the two groups(P>0.05);after treatment,the levels of serum TNF-α,hs-CRP and IL-6 in both groups were decreased(P<0.05),and the above three levels in the observation group were lower than those in the control group(P<0.05).Conclusion:The therapy of Yiqi Yangyin Huashi Prescription combined with fasting treatment in Chinese medicine has a significant curative effect on metabolic syndrome of spleen deficiency with phlegm-damp type,which can effectively improve the clinical symptoms,regulate the metabolic disorder and reduce the inflammatory responses.