夹脊盘龙针法联合多巴丝肼治疗肝肾不足型帕金森病运动障碍临床研究

Clinical Study on Acupuncture at Jiaji Points with Panlong Needling Method Com⁃bined with Levodopa and Benserazide Hydrochloride for Movement Disorders in Par⁃kinson's Disease of Liver-Kidney Insufficiency Type

目的:观察夹脊盘龙针法联合多巴丝肼治疗肝肾不足型帕金森病运动障碍的临床疗效。方法:采用随机数字表法将102例肝肾不足型帕金森病患者分为对照组、观察组各51例。对照组给予多巴丝肼治疗,观察组在对照组基础上联用夹脊盘龙针法治疗。比较2组治疗前后中医证候评分、Tinetti平衡与步态量表(POMA)评分、Barthel指数、运动神经电生理指标,并评估2组临床疗效及不良反应发生情况。结果:治疗期间,对照组脱落3例,完成研究48例;观察组脱落2例,完成研究49例。治疗后,观察组总有效率87.76%,高于对照组66.67%(P<0.05)。2组治疗后POMA(步态测试、平衡测试)评分、Barthel指数均较治疗前升高(P<0.05),中医证候评分降低(P<0.05);观察组治疗后POMA评分、Barthel指数高于对照组(P<0.05),中医证候评分低于对照组(P<0.05)。治疗后,对照组正中神经、尺神经、胫神经、腓总神经潜伏期较治疗前升高(P<0.05),观察组正中神经、尺神经、胫神经、腓总神经潜伏期降低(P<0.05),且观察组治疗后上述运动神经潜伏期低于对照组(P<0.05)。治疗后,对照组正中神经、尺神经、胫神经、腓总神经波幅较治疗前降低(P<0.05),观察组治疗后正中神经、尺神经、胫神经、腓总神经波幅升高(P<0.05);观察组治疗后上述运动神经波幅高于对照组(P<0.05)。2组均未发生严重不良反应。结论:夹脊盘龙针法联合多巴丝肼治疗肝肾不足型帕金森病疗效确切,能够提高患者运动功能,减轻周围神经损害,安全性高。

Objective:To observe the clinical effect of acupuncture at Jiaji points(EX-B2)with the Panlong needling method combined with Levodopa and Benserazide Hydrochloride for movement disorders in Parkinson's disease of liver-kidney insufficiency type.Methods:A total of 102 cases of patients with Parkinson's disease of liver-kidney insufficiency type were divided into the control group and the observation group according to the random number table method,with 51 cases in each group.The control group was treated with Levodopa and Benserazide Hydrochloride,and the observation group was treated with acupuncture at Jiaji points with the Panlong needling method based on the treatment of the control group.Traditional Chinese medicine(TCM)syndrome scores,scores of Tinetti Performance Oriented Mobility Assessment(POMA),Barthel indexes,and electrophysiologic indexes of motor nerve were compared between the two groups before and after treatment.Clinical effects and the incidence of adverse reactions were evaluated in the two groups.Results:During treatment,3 cases fell off and 48 cases were completed in the control group;2 cases fell off and 49 cases were completed in the observation group.After treatment,the total effective rate was 87.76%in the observation,higher than that of 66.67%in the control group(P<0.05).After treatment,the scores of POMA(gait test and balance test)and Barthel indexes in the two groups were increased when compared with those before treatment(P<0.05),and the TCM syndrome scores were lower than those before treatment(P<0.05);the scores of POMA and Barthel indexes in the observation group were higher than those in the control group(P<0.05),and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05).After treatment,the latency of the median nerve,ulnar nerve,tibial nerve,and common peroneal nerve in the control group was increased when compared with that before treatment(P<0.05);the latency of the median nerve,ulnar nerve,tibial nerve,and common peroneal nerve in the observation group was decreased when compared with that before treatment(P<0.05);after treatment,the above latency of motor nerves in the observation group was lower than that in the control group(P<0.05).After treatment,the amplitude of the median nerve,ulnar nerve,tibial nerve,and common peroneal nerve in the control group was decreased when compared with that before treatment(P<0.05);the amplitude of the median nerve,ulnar nerve,tibial nerve,and common peroneal nerve in the observation group was increased when compared with that before treatment(P<0.05);after treatment,the above amplitude of motor nerves in the observation group was higher than that in the control group(P<0.05).No severe adverse reactions happened in the two groups.Conclusion:Acupuncture at Jiaji points with the Panlong needling method combined with Levodopa and Benserazide Hydrochloride has a definite curative effect and high safety in the treatment of Parkinson's disease of liver-kidney insufficiency type and can improve the motor function of patients and reduce peripheral nerve damage.