血清proGRP联合NLR对淋巴结转移因素分析及甲状腺癌的诊断

Analysis of Serum proGRP Combined with NLR for Lymph Node Metastasis Factors and the Diagnosis of Thyroid Cancer

目的分析血清胃泌素释放肽前体(proGRP)联合中性粒细胞/淋巴细胞比值(NLR)对淋巴结转移的关系及甲状腺癌的诊断。方法选择2020年1月—2023年1月西安航天总医院收治的140例甲状腺结节患者作为研究对象,以病理结果为金标准,将其中70例甲状腺癌患者作为观察组,另70例甲状腺良性结节患者为对照组,同时根据观察组患者淋巴结是否转移划分为转移组(33例)和未转移组(37例)。分别比较观察组与对照组、转移组与非转移组血清proGRP及NLR指标值差异,测算血清proGRP及NLR对甲状腺癌及淋巴结转移的诊断效能。结果观察组患者proGRP及NLR指标值高于对照组,差异具有统计学意义(P<0.05),转移组患者血清proGRP及NLR指标值高于非转移组,差异具有统计学意义(P<0.05);血清proGRP联合NLR指标诊断甲状腺癌的灵敏度、特异度、准确度、阳性预测值及阴性预测值均高于各指标单独检测,差异具有统计学意义(P<0.05);血清proGRP联合NLR指标预测甲状腺癌伴淋巴结转移的灵敏度、特异度、准确度、阳性预测值及阴性预测值均高于各指标单独预测,差异具有统计学意义(P<0.05)。结论血清proGRP联合NLR对甲状腺癌具有较高的诊断价值,同时二者与甲状腺癌伴淋巴结转移关系密切,提前做好指标检测对淋巴结转移风险具有一定的预测价值。

Objective The relationship of serum gastrin-releasing peptide precursor(proGRP)combined with neutrophil/lymphocyte ratio(NLR)on lymph node metastasis and the diagnosis of thyroid cancer were analyzed.Methods The 140 patients with thyroid nodules admitted to Xi'an Aerospace General Hospital between January 2020 and January 2023 were selected as the study object,with pathological results as the gold standard,70 patients with thyroid cancer were taken as the observation group,the other 70 patients with benign thyroid nodules as the control group,and the patients were divided into metastasis group(n=33)and non metastasis group(n=37).The diagnostic effi cacy of serum proGRP and NLR in thyroid cancer and lymph node metastasis was calculated by comparing the diff erence of serum proGRP and NLR index values respectively.Results The proGRP and NLR values of patients in observation group were higher than those of control group,the diff erence was statistically signifi cant(P<0.05),and the serum proGRP and NLR values of patients in metastasis group were higher than those of non-metastasis group,and the diff erence was statistically signifi cant(P<0.05);the sensitivity,specifi city,accuracy,positive predictive value and negative predictive value of serum proGRP and NLR index were respectively higher than that of each index alone,and the difference was statistically significant(P<0.05);the sensitivity,specificity,accuracy,positive predictive value and negative predictive value of serum proGRP combined with NLR index to predict thyroid cancer with lymph node metastasis were higher than that of each index alone,and the difference was statistically significant(P<0.05).Conclusion Serum proGRP combined with NLR has high diagnostic value for thyroid cancer,and the two are closely related to thyroid cancer with lymph node metastasis,so the index detection in advance has certain predictive value for the risk of lymph node metastasis.