STAT5在辅助性T细胞分化中的研究进展

Research progress of STAT5 in helper T cells differentiation

辅助性T细胞(helper T cells,Th)是机体免疫的重要组成部分,初始T细胞接收外源刺激后可分化为不同类型的Th细胞,Th细胞异常可诱导多种疾病发生。信号转导和转录激活因子(signal transducer and activator of transcription,STAT)5编码基因均位于人类17号染色体上,是Th分化的关键调节因子,了解STAT5在Th分化中的作用有助于开发治疗Th细胞异常相关疾病的STAT5靶点药物。文章综述了STAT5在Th细胞分化中的作用及相关分子机制,以期为Th相关疾病治疗寻找新的靶点。

Helper T cells(Th)are an important part for body immunity.Initial T cells can differentiate into different types of Th after receiving exogenous stimulation.Abnormality of Th can induce many diseases.The signal transducer and activator of transcription(STAT)5 is located on human chromosome 17 and is a key regulatory factor for Th differentiation.Understanding the role of STAT5 in Th differentiation can help develop STAT5 targeted drugs for the treatment of Th abnormalities related diseases.This review summarizes the role and related molecular mechanisms of STAT5 in Th differentiation,with the aim of finding new targets for the treatment of Th related diseases.