肠道微生物在儿童孤独症谱系障碍发病中作用的研究进展

Research progress on the role of gutmicrobiome in the pathogenesis of autism spectrum disorders in children

孤独症谱系障碍(autism spectrum disorder,ASD)是以社会交往、交流障碍和重复刻板行为、兴趣狭窄为核心特征的神经发育障碍性疾病。肠道微生物能通过肠-脑轴与中枢神经系统建立双向连接,影响人类的认知和情绪。近年来,大量研究发现,ASD患者肠道微生物发生了改变,肠道菌群的失调可能参与了ASD的发生和发展。文章总结了微生物-肠-脑轴在ASD中的潜在作用及微生物靶向治疗的最新进展,以期为肠道菌群改善ASD相关症状的潜在可能提供依据。

Autism spectrum disorder(ASD)is a neurodevelopmental disorder characterized by social interaction,communication disorder,repetitive stereotyped behavior and narrow interest.Gut microbiome can establish a two-way connection with the central nervous system through the gut brain axis and affect human cognition and emotion.In recent years,a large number of studies have found that the intestinal microorganisms of ASD patients have changed,and the imbalance of intestinal flora may participate in the occurrence and development of ASD.This review summarizes the potential role of microbiota-gut-brain axis in ASD and the latest progress of microbiota targeted therapy,in order to provide evidence for the gut microbiota to improve ASD related symptoms.