冷冻消融治疗肾上腺肿瘤的临床应用及进展

Clinical application and research progress of cryoablation for adrenal tumors

肾上腺肿瘤在人群中的发病率约为1%,手术切除为首选治疗方式。近年来,许多微创介入技术治疗肾上腺肿瘤取得了较为显著的效果。其中冷冻消融术以其创伤小、恢复快、可重复、安全性高、并发症较少等诸多优势,已应用于治疗肾上腺肿瘤,并取得了医患双方的认可。因此冷冻消融是未来肾上腺肿瘤治疗的发展方向,可以改善局部症状,减轻肿瘤负荷,提高患者的生活质量,延长患者的生存期。本文对冷冻消融术治疗肾上腺肿瘤的原理机制、冷冻设备、引导方式,以及在醛固酮瘤、嗜铬细胞瘤、肾上腺皮质腺癌、肾上腺转移瘤中的临床应用,存在的优势与不足及相关并发症进行综述。

The incidence of adrenal tumors in the population is approximately 1%,and surgical resection is the preferred treatment.In recent years,many minimally-invasive interventional techniques have achieved remarkable therapeutic effects in the treatment of adrenal tumors.Among them,cryoablation has been successfully used in the treatment of adrenal tumors with lots of advantages such as small trauma,rapid recovery,repeatability,high safety,and fewer complications,and this therapy has already been recognized by both doctors and patients.Therefore,cryoablation will be the development direction of the treatment of adrenal tumors,it can improve local symptoms,reduce tumor burden,improve patient's quality of life,and prolong patient's survival time.This paper aims to make a comprehensive review on the principles and mechanism of cryoablation for adrenal tumors,cryoablation equipment,guidance methods of cryoablation,its clinical application in treating aldosteronoma,pheochromocytoma,adrenal cortical adenocarcinoma,adrenal metastases,etc.Its advantages,disadvantages,and procedure-related complications are also introduced.