摘要
风湿免疫性疾病是指由于多种原因使体内免疫功能紊乱而引起的疾病,发病机制复杂且发病率高,易反复发作。自身免疫耐受机制失调会产生多种针对自身细胞、组织及器官的自身抗体。目前已发现越来越多的风湿免疫性疾病相关自身抗体与临床表现、疾病过程、临床并发症及预后存在关联。总结自身抗体的临床意义对风湿免疫性疾病的早期诊断、病情活动度评估、预后判断尤为重要。
Rheumatic immune disease is a kind of autoimmune disease caused by the disorder of immune function in the body due to various reasons.The pathogenesis of autoimmune disease is complex.The imbalance of autoimmune tolerance mechanism will produce a variety of autoantibodies against self-cells,tissues and organs.At present,more and more autoantibodies related to rheumatic immune diseases have been found associated with clinical manifestations,disease process,clinical complications and prognosis.It is particularly important to summarize the clinical significance of autoantibodies for early diagnosis,assessment of disease activity and prognosis of rheumatic immune diseases.
作者
张馨月
池旭阳
马晓雪
Zhang Xinyue;Chi Xuyang;Ma Xiaoxue(Pediatrics Department of the First Affiliated Hospital of China Medical University,Shenyang 110001,China;Pediatrics Department of Benxi Central Hospital of China Medical University,Benxi 117000,China)
出处
《国际免疫学杂志》
CAS
2023年第4期444-449,共6页
International Journal of Immunology
基金
国家自然科学基金(81901658)
辽宁省自然科学基金(2022-BS-134)。
