摘要
阿尔茨海默病(AD)是主要损害认知和记忆功能的中枢神经系统退行性疾病,AD的发病机制尚未完全阐明,近年研究表明神经炎症反应在AD发病机制中起着关键的作用,Toll样受体4(TLR4)作为AD中神经炎症的一个触发点,为AD的治疗提供了潜在的靶点,本文就此做一综述以期为AD的临床治疗提供参考借鉴。
Alzheimer's disease(AD)is a degenerative disease of the central nervous system that mainly damages cognitive and memory functions.The pathogenesis of AD has not been fully elucidated.Recent studies have shown that neuroinflammatory response plays a key role in the pathogenesis of AD.As a trigger point of neuroinflammation in AD,Toll-like receptor 4(TLR4)provides a potential target for the treatment of AD.This review aims to provide references for clinical treatment of AD.
作者
刘天姿
王宝军
Tianzi Liu;Baojun Wang(Baotou Clinical College,Inner Mongolia Medical University,Baotou 014040,China;Department of Neurology,Baotou Central Hospital,Baotou 014040,China)
出处
《中华脑血管病杂志（电子版）》
2023年第4期404-409,共6页
Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
基金
国家自然科学基金项目(81860210)。
